Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mairinger, M; Maget, A; Wagner-Skacel, J; Mörkl, S; Dalkner, N; Hellinger, T; Birner, A; Fellendorf, FT; Platzer, M; Kreuzer, K; Queissner, R; Reininghaus, B; Lenger, M; Fabisch, K; Fitz, W; Kohlhammer-Dohr, A; Krammer, A; Holl, AK; Painold, A; Häussl, A; Stross, TM; Schmiedhofer, F; Tmava-Berisha, A; Pahsini, K; Marinschek, S; Wenninger, J; Hamm, C; Pilz, R; Lehofer, M; Amouzadeh-Ghadikolai, O; Horvath, A; Kainz, G; Gallé, B; Dinan, TG; Butler, MI; Reininghaus, E; Bengesser, S.
Gut Microbiome Composition and Its Association with Sleep in Major Psychiatric Disorders.
Neuropsychobiology. 2023; 82(4): 220-233.
Doi: 10.1159/000530386
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leal Garcia Sabrina
- Mairinger Marco
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Dalkner Nina
- Fabisch Karin
- Fellendorf Frederike
- Fitz Werner
- Gallé Birgit
- Hamm Carlo
- Häussl Alfred Alois
- Holl Anna
- Horvath Angela
- Kainz Gudrun
- Kohlhammer-Dohr Alexandra
- Krammer Alexandra
- Kreuzer Kathrin
- Lenger Melanie
- Maget Alexander
- Marinschek Sabine
- Pahsini Karoline
- Painold Annamaria
- Pilz Rene
- Platzer Martina
- Queissner Robert
- Reininghaus Bernd
- Reininghaus Eva
- Schmiedhofer Franziska
- Stross Tatjana Maria
- Tmava-Berisha Adelina
- Wagner-Skacel Jolana
- Wenninger Julian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- INTRODUCTION: Sleep disturbances are highly prevalent across most major psychiatric disorders. Alterations in the hypothalamic-pituitary-adrenal axis, neuroimmune mechanisms, and circadian rhythm disturbances partially explain this connection. The gut microbiome is also suspected to play a role in sleep regulation, and recent studies suggest that certain probiotics, prebiotics, synbiotics, and fecal microbiome transplantation can improve sleep quality. METHODS: We aimed to assess the relationship between gut-microbiota composition, psychiatric disorders, and sleep quality in this cross-sectional, cross-disorder study. We recruited 103 participants, 63 patients with psychiatric disorders (major depressive disorder [n = 31], bipolar disorder [n = 13], psychotic disorder [n = 19]) along with 40 healthy controls. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). The fecal microbiome was analyzed using 16S rRNA sequencing, and groups were compared based on alpha and beta diversity metrics, as well as differentially abundant species and genera. RESULTS: A transdiagnostic decrease in alpha diversity and differences in beta diversity indices were observed in psychiatric patients, compared to controls. Correlation analysis of diversity metrics and PSQI score showed no significance in the patient and control groups. However, three species, Ellagibacter isourolithinifaciens, Senegalimassilia faecalis, and uncultured Blautia sp., and two genera, Senegalimassilia and uncultured Muribaculaceae genus, were differentially abundant in psychiatric patients with good sleep quality (PSQI >8), compared to poor-sleep quality patients (PSQI ≤8). CONCLUSION: In conclusion, this study raises important questions about the interconnection of the gut microbiome and sleep disturbances.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Gastrointestinal Microbiome - genetics
- Depressive Disorder, Major - administration & dosage
- RNA, Ribosomal, 16S - genetics
- Cross-Sectional Studies - administration & dosage
- Hypothalamo-Hypophyseal System - administration & dosage
- Pituitary-Adrenal System - administration & dosage
- Mental Disorders - diagnosis
- Sleep - administration & dosage
- Sleep Wake Disorders - administration & dosage
- Find related publications in this database (Keywords)
- Sleep
- Gut microbiome
- Butyrate
- Psychiatric disorders
- Sleep disturbance