Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kiessling, M; Djalinac, N; Voglhuber, J; Ljubojevic-Holzer, S.
Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact.
Biomedicines. 2023; 11(3):
Doi: 10.3390/biomedicines11030960
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- Führende Autor*innen der Med Uni Graz
- Holzer Senka
- Kießling Mara Luisa
- Co-Autor*innen der Med Uni Graz
- Voglhuber Julia
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- Abstract:
- The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+-regulatory mechanisms and important effects on cardiac gene expression. In this review, we (1) provide a comprehensive overview of the current state of research on the dynamics and regulation of nuclear Ca2+ signaling in cardiomyocytes, (2) address the role of nuclear Ca2+ in the development and progression of cardiac pathologies, such as heart failure and atrial fibrillation, and (3) discuss novel aspects of experimental methods to investigate nuclear Ca2+ handling and its downstream effects in the heart. Finally, we highlight current challenges and limitations and recommend future directions for addressing key open questions.
- Find related publications in this database (Keywords)
- nuclear calcium
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- atrial fibrillation