Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hasiba-Pappas, S; Kamolz, LP; Luze, H; Nischwitz, SP; Holzer-Geissler, JCJ; Tuca, AC; Rienmüller, T; Polz, M; Ziesel, D; Winter, R.
Does Electrical Stimulation through Nerve Conduits Improve Peripheral Nerve Regeneration?-A Systematic Review.
J Pers Med. 2023; 13(3):
Doi: 10.3390/jpm13030414
[OPEN ACCESS]
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Geißler Judith Christine Julie
- Kamolz Lars-Peter
- Luze Hanna
- Nischwitz Sebastian
- Tuca Alexandru
- Winter Raimund
- Ziesel Daniel
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- Abstract:
- BACKGROUND: Peripheral nerve injuries affect over 2% of trauma patients and can lead to severe functional impairment and permanent disability. Autologous nerve transplantation is still the gold standard in the reconstruction of nerve defects. For small defects, conduits can be considered for bridging. Lately, the combined use of conduits and electrical stimulation has gained attention in the treatment of peripheral nerve injury. This review aimed to present the currently available data on this topic. METHODS: PubMed, Embase, Medline and the Cochrane Library were searched for studies on electrical stimulation through nerve conduits for nerve defects in in vivo studies. RESULTS: Fifteen studies fit the inclusion criteria. All of them reported on the application of nerve conduits combined with stimulation for sciatic nerve gaps in rats. Functional, electrophysiological and histological evaluations showed improved nerve regeneration after electrical stimulation. High variation was observed in the treatment protocols. CONCLUSION: Electrically stimulated conduits could improve peripheral nerve regeneration in rat models. The combined application of nerve guidance conduits and electrical stimulation shows promising results and should be further evaluated under standardized conditions.
- Find related publications in this database (Keywords)
- nerve regeneration
- electrical stimulation
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- sciatic nerve
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