Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Voumard, B; Stefanek, P; Pretterklieber, M; Pahr, D; Zysset, P.
Influence of aging on mechanical properties of the femoral neck using an inverse method
BONE REP. 2022; 17: 101638
Doi: 10.1016/j.bonr.2022.101638
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- Co-Autor*innen der Med Uni Graz
- Pretterklieber Michael
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- Abstract:
- Today, we are facing rapid aging of the world population, which increases the incidence of hip fractures. The gold standard of bone strength assessment in the laboratory is micro-computed finite element analysis (mu FEA) based on micro-computed tomography (mu CT) images. In clinics, the standard method to assess bone fracture risk is based on areal bone mineral density (aBMD), measured by dual-energy X-ray absorptiometry (DXA). In addition, homogenized finite element analysis (hFEA) constructed from quantitative computed tomography reconstructions (QCT) predicts clinical bone strength more accurately than DXA. Despite considerable evidence of degradation of bone material properties with age, in the past fifty years of finite element analysis to predict bone strength, bone material parameters remained independent of age. This study aims to assess the influence of age on apparent modulus, yield stress, and strength predictions of the human femoral neck made by laboratory -available bone volume fraction (BV/TV) and mu FEA; and by clinically available DXA and hFEA. Using an inverse method, we test the hypothesis that FEA material parameters are independent of age. Eighty-six human femora were scanned with DXA (aBMD) and with QCT. The femoral necks were extracted and scanned at 16 mu m reso-lution with mu CT. The grayscale images were downscaled to 32 mu m and 65 mu m for linear and non-linear analyses, respectively, and segmented. The mu FE solver ParOSolNL (non-linear) and a standard hFEA method were applied to the neck sections with the same material properties for all samples to compute apparent modulus, yield stress, and strength. Laboratory-available BV/TV was a good predictor of apparent modulus (R2 = 0.76), almost as good as mu FEA (R2 = 0.79). However, yield stress and strength were better predicted by mu FEA (R2 = 0.92, R2 = 0.86, resp.) than BV/TV (R2 = 0.76, R2 = 0.76, resp.). For clinically available variables, prediction of apparent modulus was better with hFEA than aBMD (R2 = 0.67, R2 = 0.58, resp.). hFEA outperformed aBMD for pre-dictions of yield stress (R2 = 0.63 vs R2 = 0.34 for female and R2 = 0.55 for male) and strength (R2 = 0.48 vs R2 = 0.33 for female and R2 = 0.15 for male). The inclusion of age did not improve the multiple linear models for apparent modulus, yield stress, and strength. The resolution of the mu FE meshes seems to account for most morphological changes induced by aging. The errors between the simulation and the experiment for apparent modulus, yield stress, and strength were age-independent, suggesting no rationale for correcting tissue material parameters in the current FE analysis of the aging femoral neck.
- Find related publications in this database (Keywords)
- Femoral neck
- Bone aging
- Bone mechanical properties
- Micro finite element
- Homogenized finite element
- DXA
- Bone strength prediction