Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stadler, JT; Mangge, H; Rani, A; Curcic, P; Herrmann, M; Prüller, F; Marsche, G.
Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19.
Antioxidants (Basel). 2022; 11(10):
Doi: 10.3390/antiox11101858
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- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Marsche Gunther
- Stadler Julia
- Co-Autor*innen der Med Uni Graz
- Curcic Pero
- Herrmann Markus
- Prüller Florian
- RANI Alankrita
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- Abstract:
- Plasma membrane cholesterol is required for proper trafficking and localization of receptors that facilitate severe acute respiratory syndrome coronavirus 2 infection. High-density lipoproteins (HDL) mobilize plasma membrane cholesterol, and HDL-cholesterol levels are associated with the severity of COVID-19 disease and mortality. However, HDL-cholesterol levels poorly reflect the function of this complex family of particles, and a detailed assessment of COVID-19-associated changes in HDL functionality and its prognostic value is lacking. In the present study, we assessed HDL cholesterol efflux capacity, HDL anti-inflammatory and antioxidant properties, and changes in HDL composition and metabolism in COVID-19 (n = 48) and non-COVID pneumonia patients (n = 32). COVID-19 infection markedly reduced the activity of lecithin-cholesteryl-acyltransferase and functional parameters of HDL, such as the cholesterol efflux capacity, arylesterase activity of paraoxonase 1, and anti-oxidative capacity of apoB-depleted serum when compared to non-COVID pneumonia at baseline, paralleled by markedly reduced levels of HDL-cholesterol. Of particular interest, low HDL cholesterol efflux capacity was associated with increased mortality risk in COVID-19 patients, independent of HDL-C levels. Our results highlight profound effects of COVID-19 infection on HDL function, metabolism, and composition. Low HDL cholesterol efflux capacity indicates a fatal course of COVID-19, independent of HDL-cholesterol levels.
- Find related publications in this database (Keywords)
- COVID-19
- HDL
- cholesterol efflux capacity
- LCAT
- anti-oxidative capacity
- PON1