Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jandl, K; Mutgan, AC; Eller, K; Schaefer, L; Kwapiszewska, G.
The basement membrane in the cross-roads between the lung and kidney.
Matrix Biol. 2022; 105: 31-52.
Doi: 10.1016/j.matbio.2021.11.003
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Jandl Katharina
- Kwapiszewska-Marsh Grazyna
- Co-Autor*innen der Med Uni Graz
- Eller Kathrin
- Mutgan Redolfi Ayse Ceren
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- Abstract:
- The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessive remodeling of the BM, which is a hallmark of both inflammatory and fibrosing diseases in the lung and the kidney, can lead to the release of BM-derived matrikines, proteolytic fragments with distinct biological functions. These matrikines can then influence disease activity at the site of liberation. However, they are also released to the circulation, where they can directly affect the vascular endothelium or target other organs, leading to extrapulmonary or extrarenal manifestations. In this review, we will summarize the current knowledge of the composition and function of the BM and its matrikines in health and disease, both in the lung and in the kidney. By comparison, we will highlight, why the BM and its matrikines may be central in establishing a renal-pulmonary interaction axis.
- Find related publications in this database (Keywords)
- Extracellular matrix
- Matrikines
- Inflammation
- Type IV collagen
- Toll-like receptor
- Endostatin