Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Urdl, W; Apter, D; Alperstein, A; Koll, P; Schönian, S; Bringer, J; Fisher, AC; Preik, M; ORTHO EVRA/EVRA 003 Study Group.
Contraceptive efficacy, compliance and beyond: factors related to satisfaction with once-weekly transdermal compared with oral contraception.
Eur J Obstet Gynecol Reprod Biol. 2005; 121(2):202-210
Doi: 10.1016/j.ejogrb.2005.01.021
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PubMed
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- Urdl Wolfgang
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- Abstract:
- OBJECTIVE: To investigate contraceptive efficacy, compliance and user's satisfaction with transdermal versus oral contraception (OC). Study design: Randomized, open-label, parallel-group trial conducted at 65 centers in Europe and South Africa. One thousand four hundred and eighty-nine women received a contraceptive patch (n = 846) or an OC (n = 643) for 6 or 13 cycles. RESULTS: Overall/method-failure Pearl Indices were 0.88/0.66 with the patch and 0.56/0.28 with the OC (p = n.s.). Compliance was higher at all age groups with the patch compared to the OC. Significantly more users were very satisfied with the contraceptive patch than with the OC. The percentage of patch users being very satisfied increased with age whereas it did not in the OC group. Likewise, improvements of premenstrual symptoms as well as emotional and physical well-being increased with age in the patch-group in contrast to the OC group. Ratings of satisfaction with the study medication correlated weakly with emotional (r = 0.33) and physical well-being (r = 0.39) as well as premenstrual symptoms (r = 0.30; p < 0.001). CONCLUSION: Contraceptive efficacy of the patch is comparable to OC, but compliance is consistently better at all age groups. Higher satisfaction with the patch at increasing age may be attributed to improvements in emotional and physical well-being as well as reduction of premenstrual symptoms.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous -
- Administration, Oral -
- Adult -
- Contraceptive Agents, Female - administration and dosage
- Contraceptives, Oral, Hormonal - administration and dosage
- Drug Administration Schedule - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Patient Compliance - administration and dosage
- Patient Satisfaction - administration and dosage
- Treatment Outcome - administration and dosage
- Find related publications in this database (Keywords)
- transdermal contraceptive patch
- oral contraceptive
- efficacy
- safety
- compliance
- satisfaction