Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lin, WY; Fordham, SE; Hungate, E; Sunter, NJ; Elstob, C; Xu, Y; Park, C; Quante, A; Strauch, K; Gieger, C; Skol, A; Rahman, T; Sucheston-Campbell, L; Wang, J; Hahn, T; Clay-Gilmour, AI; Jones, GL; Marr, HJ; Jackson, GH; Menne, T; Collin, M; Ivey, A; Hills, RK; Burnett, AK; Russell, NH; Fitzgibbon, J; Larson, RA; Le, Beau, MM; Stock, W; Heidenreich, O; Alharbi, A; Allsup, DJ; Houlston, RS; Norden, J; Dickinson, AM; Douglas, E; Lendrem, C; Daly, AK; Palm, L; Piechocki, K; Jeffries, S; Bornhäuser, M; Röllig, C; Altmann, H; Ruhnke, L; Kunadt, D; Wagenführ, L; Cordell, HJ; Darlay, R; Andersen, MK; Fontana, MC; Martinelli, G; Marconi, G; Sanz, MA; Cervera, J; Gómez-Seguí, I; Cluzeau, T; Moreilhon, C; Raynaud, S; Sill, H; Voso, MT; Lo-Coco, F; Dombret, H; Cheok, M; Preudhomme, C; Gale, RE; Linch, D; Gaal-Wesinger, J; Masszi, A; Nowak, D; Hofmann, WK; Gilkes, A; Porkka, K; Milosevic, Feenstra, JD; Kralovics, R; Grimwade, D; Meggendorfer, M; Haferlach, T; Krizsán, S; Bödör, C; Stölzel, F; Onel, K; Allan, JM.
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Nat Commun. 2021; 12(1): 6233
Doi: 10.1038/s41467-021-26551-x
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- Co-Autor*innen der Med Uni Graz
- Sill Heinz
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- Abstract:
- Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10-8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10-10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).