Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mosbacher, JA; Waser, M; Garn, H; Seiler, S; Coronel, C; Dal-Bianco, P; Benke, T; Deistler, M; Ransmayr, G; Mayer, F; Sanin, G; Lechner, A; Lackner, HK; Schwingenschuh, P; Grossegger, D; Schmidt, R.
Functional (un-)Coupling: Impairment, Compensation, and Future Progression in Alzheimer's Disease.
Clin EEG Neurosci. 2023; 54(3):316-326
Doi: 10.1177/15500594211052208
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Mosbacher Jochen
- Schmidt Reinhold
- Co-Autor*innen der Med Uni Graz
- Lackner Helmut Karl
- Lechner Anita
- Schwingenschuh Petra
- Seiler Stephan
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- Abstract:
- Background: Functional (un-)coupling (task-related change of functional connectivity) between different sites of the brain is a mechanism of general importance for cognitive processes. In Alzheimer's disease (AD), prior research identified diminished cortical connectivity as a hallmark of the disease. However, little is known about the relation between the amount of functional (un-)coupling and cognitive performance and decline in AD. Method: Cognitive performance (based on CERAD-Plus scores) and electroencephalogram (EEG)-based functional (un-)coupling measures (connectivity changes from rest to a Face-Name-Encoding task) were assessed in 135 AD patients (age: M = 73.8 years; SD = 9.0). Of these, 68 patients (M = 73.9 years; SD = 8.9) participated in a follow-up assessment of their cognitive performance 1.5 years later. Results: The amounts of functional (un-)coupling in left anterior-posterior and homotopic interhemispheric connections in beta1-band were related to cognitive performance at baseline (β = .340; p < .001; β = .274; P = .001, respectively). For both markers, a higher amount of functional coupling was associated with better cognitive performance. Both markers also were significant predictors for cognitive decline. However, while patients with greater functional coupling in left anterior-posterior connections declined less in cognitive performance (β = .329; P = .035) those with greater functional coupling in interhemispheric connections declined more (β = -.402; P = .010). Conclusion: These findings suggest an important role of functional coupling mechanisms in left anterior-posterior and interhemispheric connections in AD. Especially the complex relationship with cognitive decline in AD patients might be an interesting aspect for future studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Aged - administration & dosage
- Alzheimer Disease - administration & dosage
- Magnetic Resonance Imaging - administration & dosage
- Electroencephalography - methods
- Cognitive Dysfunction - administration & dosage
- Brain - administration & dosage
- Disease Progression - administration & dosage
- Find related publications in this database (Keywords)
- dementia
- Alzheimer's disease
- EEG
- functional connectivity
- functional coupling
- cognition