Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zelzer, S; Prüller, F; Curcic, P; Sloup, Z; Holter, M; Herrmann, M; Mangge, H.
Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients.
Nutrients. 2021; 13(7):
Doi: 10.3390/nu13072129
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Prüller Florian
- Zelzer Sieglinde
- Co-Autor*innen der Med Uni Graz
- Curcic Pero
- Herrmann Markus
- Holter Magdalena
- Sloup Zdenka
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- (1) Background: Vitamin D, a well-established regulator of calcium and phosphate metabolism, also has immune-modulatory functions. An uncontrolled immune response and cytokine storm are tightly linked to fatal courses of COVID-19. The present retrospective study aimed to inves-tigate vitamin D status markers and vitamin D degradation products in a mixed cohort of 148 hospitalized COVID-19 patients with various clinical courses of COVID-19. (2) Methods: The serum concentrations of 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, and 25,26(OH)2D3 were determined by a validated liquid-chromatography tandem mass-spectrometry method in leftover serum samples from 148 COVID-19 patients that were admitted to the University Hospital of the Medical Uni-versity of Graz between April and November 2020. Anthropometric and clinical data, as well as outcomes were obtained from the laboratory and hospital information systems. (3) Results: From the 148 patients, 34 (23%) died within 30 days after admission. The frequency of fatal outcomes did not differ between males and females. Non-survivors were significantly older than survivors, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently. The serum concentrations of all vitamin D metabolites and the vitamin D metabolite ratio (VMR) did not differ significantly between survivors and non-survivors. Additionally, the need for res-piratory support was unrelated to the serum concentrations of 25(OH)D vitamin D and the two vitamin D catabolites, as well as the VMR. (4) Conclusion: The present results do not support a relevant role of vitamin D for the course and outcome of COVID-19.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Biomarkers - blood
- COVID-19 - blood, mortality
- Chromatography, Liquid - methods
- Ergocalciferols - blood
- Female - administration & dosage
- Hospitalization - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Respiration, Artificial - statistics & numerical data
- Retrospective Studies - administration & dosage
- SARS-CoV-2 - administration & dosage
- Tandem Mass Spectrometry - methods
- Vitamin D - analogs & derivatives, blood
- Vitamin D Deficiency - blood
- Vitamins - blood
- Find related publications in this database (Keywords)
- vitamin D metabolites
- COVID19
- clinical outcome