Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lax, SF; Skok, K; Zechner, PM; Setaffy, L; Kessler, HH; Kaufmann, N; Vander, K; Cokić, N; Maierhofer, U; Bargfrieder, U; Trauner, M.
[Systemic consequences and clinical aspects of SARS-CoV-2 infection].
PATHOLOGE. 2021; 42(2): 155-163.
Doi: 10.1007/s00292-021-00913-0
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- Führende Autor*innen der Med Uni Graz
- Lax Sigurd
- Co-Autor*innen der Med Uni Graz
- Kessler Harald
- Skok Kristijan
- Trauner Michael
- Zechner Peter
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- Abstract:
- COVID-19 is considered a systemic disease. A severe course with fatal outcome is possible and unpredictable. Which organ systems are predominantly involved? Which diseases are predisposed for a fatal course? Which organ changes are found with lethal outcome? Data from published autopsy studies (28 cases by our group) with respect to organ changes and possible cause of death. The most severe alterations are found in the lungs by diffuse alveolar damage as a symptom of an acute respiratory distress syndrome (ARDS), in part with fibrosis. Thrombosis of small- to mid-sized pulmonary arteries is associated with hemorrhagic lung infarction. Frequent complications are bacterial pneumonias and less frequently fungal pneumonias by aspergillus. Pulmonary thromboembolism is found in 20-30% of lethal courses, also in the absence of deep venous thrombosis. Intestinal involvement of COVID-19 can be associated with intestinal ischemia, caused by shock or local thrombosis. In most cases, the kidneys display acute tubular injury reflecting acute renal failure, depletion of lymphocytes in the lymph nodes and spleen, and hyperplastic adrenal glands. The liver frequently reveals steatosis, liver cell necrosis, portal inflammation, and proliferation of Kupffer cells. Important preexisting diseases in autopsy studies are arterial hypertension with hypertensive and ischemic cardiomyopathy and diabetes mellitus but large population-based studies reveal increased risk of mortality only for diabetes mellitus not for arterial hypertension. Alterations of the pulmonary circulation with pulmonary arterial thrombosis, infarction, and bacterial pneumonia are important and often lethal complications of COVID-19-associated ARDS. Findings from autopsy studies have influenced therapy and prophylaxis.
- Find related publications in this database (using NLM MeSH Indexing)
- Autopsy -
- COVID-19 -
- Humans -
- Lung -
- SARS-CoV-2 -
- Thrombosis -
- Find related publications in this database (Keywords)
- Autopsy
- COVID-19
- Ischemic bowel disease
- Respiratory distress syndrome
- Pulmonary thrombosis