Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Auner, HW; Zebisch, A; Ofner, P; Sill, H; Linkesch, W; Krause, R.
Evaluation of potential risk factors for early infectious complications after autologous peripheral blood stem cell transplantation in patients with lymphoproliferative diseases.
ANN HEMATOL. 2005; 84: 532-537.
Doi: 10.1007/s00277-005-1025-5
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- Co-Autor*innen der Med Uni Graz
- Krause Robert
- Linkesch Werner
- Ofner-Kopeinig Petra
- Sill Heinz
- Zebisch Armin
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- Abstract:
- A number of risk factors for the occurrence of neutropaenic fever after haematopoietic stem cell transplantation (HSCT) have been proposed. We were interested in whether these factors remain valid for several early infection-related outcomes when applied to a homogeneous group of patients in uni- and multivariate analyses. Therefore, we analysed 144 consecutive patients with lymphoproliferative disorders receiving autologous peripheral blood HSCT. Variables tested as potential risk factors for the occurrence of fever, documented infection (DI), microbiologically documented infection (MDI) or failure of first-line antimicrobial therapy were sex, conditioning regimen, prolonged neutropaenia, low number of CD34+ cells transplanted, purging, lack of selective gut decontamination, higher age and increased body mass index. In uni- and multivariate analyses, conditioning including total body irradiation was the only risk factor for the occurrence of fever, and neutropaenia >or=10 days was the only factor associated with failure of first-line antimicrobial therapy. None of the variables tested was associated with an increased risk for DI or MDI. This analysis suggests that a number of previously proposed risk factors actually are of minor clinical relevance for early infections in the majority of patients receiving autologous HSCT.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Analysis of Variance -
- Anti-Infective Agents - pharmacology
- Female - pharmacology
- Fever - etiology
- Humans - etiology
- Lymphoproliferative Disorders - complications
- Male - complications
- Middle Aged - complications
- Neutropenia - complications
- Opportunistic Infections - etiology
- Peripheral Blood Stem Cell Transplantation - adverse effects
- Research Support, Non-U.S. Gov't - adverse effects
- Risk Factors - adverse effects
- Transplantation Conditioning - adverse effects
- Transplantation, Autologous - adverse effects
- Find related publications in this database (Keywords)
- autologous stem cell transplantation
- high-dose chemotherapy
- infection
- risk factor