Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Monecke, S; König, E; Earls, MR; Leitner, E; Müller, E; Wagner, GE; Poitz, DM; Jatzwauk, L; Vremerǎ, T; Dorneanu, OS; Simbeck, A; Ambrosch, A; Zollner-Schwetz, I; Krause, R; Ruppitsch, W; Schneider-Brachert, W; Coleman, DC; Steinmetz, I; Ehricht, R.
An epidemic CC1-MRSA-IV clone yields false-negative test results in molecular MRSA identification assays: a note of caution, Austria, Germany, Ireland, 2020.
Euro Surveill. 2020; 25(25):
Doi: 10.2807/1560-7917.ES.2020.25.25.2000929
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- Führende Autor*innen der Med Uni Graz
- König Elisabeth
- Leitner-Meyer Eva
- Co-Autor*innen der Med Uni Graz
- Krause Robert
- Steinmetz Ivo
- Wagner-Lichtenegger Gabriel
- Zollner-Schwetz Ines
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- Abstract:
- We investigated why a clinical meticillin-resistant Staphylococcus aureus (MRSA) isolate yielded false-negative results with some commercial PCR tests for MRSA detection. We found that an epidemic European CC1-MRSA-IV clone generally exhibits this behaviour. The failure of the assays was attributable to a large insertion in the orfX/SCCmec integration site. To ensure the reliability of molecular MRSA tests, it is vital to monitor emergence of new SCCmec types and junction sites.