Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Golob-Schwarzl, N; Puchas, P; Gogg-Kamerer, M; Weichert, W; Göppert, B; Haybaeck, J.
New Pancreatic Cancer Biomarkers eIF1, eIF2D, eIF3C and eIF6 Play a Major Role in Translational Control in Ductal Adenocarcinoma.
Anticancer Res. 2020; 40(6):3109-3118
Doi: 10.21873/anticanres.14292
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- Führende Autor*innen der Med Uni Graz
- Golob-Schwarzl Nicole
- Haybäck Johannes
- Co-Autor*innen der Med Uni Graz
- Gogg-Kamerer Margit
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- Abstract:
- Pancreatic cancer is one of the deadliest forms of cancer and ranks among the leading causes of cancer-related death worldwide. The most common histological type is ductal adenocarcinoma (PDAC), accounting for approximately 95% of cases. Deregulation of protein synthesis has been found to be closely related to cancer. The rate-limiting step of translation is initiation, which is regulated by a broad range of eukaryotic translation initiation factors (eIFs). Human PDAC samples were biochemically analyzed for the expression of various eIF subunits on the protein level (immunohistochemistry, immunoblot analyses) in 174 cases of PDAC in comparison with non-neoplastic pancreatic tissue (n=10). Our investigation revealed a significant down-regulation of four specific eIF subunits, namely eIF1, eIF2D, eIF3C and eIF6. Concomitantly, the protein (immunoblot) levels of eIF1, eIF2D, eIF3C and eIF6 were reduced in PDAC samples as compared with non-neoplastic pancreatic tissue. Members of the eIF family are of relevance in pancreatic tumor biology and may play a major role in translational control in PDAC. Consequently, they might be useful as potential new biomarkers and therapeutic targets in PDAC. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor - genetics
- Biomarkers, Tumor - metabolism
- Carcinoma, Pancreatic Ductal - genetics
- Carcinoma, Pancreatic Ductal - metabolism
- Carcinoma, Pancreatic Ductal - pathology
- Down-Regulation -
- Eukaryotic Initiation Factors - biosynthesis
- Eukaryotic Initiation Factors - genetics
- Eukaryotic Initiation Factors - metabolism
- Humans -
- Immunohistochemistry -
- Pancreatic Neoplasms - genetics
- Pancreatic Neoplasms - metabolism
- Phosphatidylinositol 3-Kinases - metabolism
- Proto-Oncogene Proteins c-akt - metabolism
- Signal Transduction -
- Survival Rate -
- TOR Serine-Threonine Kinases - metabolism
- Tissue Array Analysis -
- Find related publications in this database (Keywords)
- Pancreatic cancer
- eukaryotic translation initiation factors
- PI3K/AKT/mTOR pathway
- biomarker