Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Berger, A; Santic, R; Hauser-Kronberger, C; Schilling, FH; Kogner, P; Ratschek, M; Gamper, A; Jones, N; Sperl, W; Kofler, B.
Galanin and galanin receptors in human cancers.
NEUROPEPTIDES 2005 39: 353-359.
Doi: 10.1016/j.npep.2004.12.016
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- Co-Autor*innen der Med Uni Graz
- Ratschek Manfred
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- Abstract:
- The increasing interest in peptides and peptide receptors in cancer is based on the possibility of receptor targeting, because peptide receptors are often expressed in different human tumors. The neuropeptide galanin has also been suggested to be involved in the development of neuroendocrine tumors based on the development of estrogen-induced tumors in estrogen-sensitive rats. This study summarizes our current knowledge on the expression of galanin peptide and galanin receptors in different human neuroendocrine tumors. The expression of both, peptide and corresponding receptor, seems to be a common feature of human gliomas, pheochromocytomas, pituitary and neuroblastic tumors. The co-expression of galanin and its receptors supports a role for galanin in tumor cell pathology via autocrine/paracrine mechanisms.
- Find related publications in this database (using NLM MeSH Indexing)
- Galanin - physiology
- Humans - physiology
- Neoplasms - physiopathology
- Receptors, Galanin - physiology
- Research Support, Non-U.S. Gov't - physiology
- Find related publications in this database (Keywords)
- galanin
- galanin receptor
- cancer