Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Patra, V; Wagner, K; Arulampalam, V; Wolf, P.
Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function.
iScience. 2019; 15: 211-222.
Doi: 10.1016/j.isci.2019.04.026
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- Führende Autor*innen der Med Uni Graz
- Patra Vijaykumar
- Wolf Peter
- Co-Autor*innen der Med Uni Graz
- Wagner Karin
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- Abstract:
- The skin is colonized by a diverse microbiome intricately involved in various molecular and cellular processes within the skin and beyond. UV radiation is known to induce profound changes in the skin and modulate the immune response. However, the role of the microbiome in UV-induced immune suppression has been overlooked. By employing the standard model of contact hypersensitivity (using germ-free mice) we found diminished UV-induced systemic immune suppression in the presence of microbiome. Upon UV exposure, we found enhanced epidermal hyperplasia and neutrophilic infiltration in the presence and enhanced numbers of mast cells and monocyte or macrophages in the absence of microbiome. Transcriptome analysis revealed a predominant expression of cytokine genes related to pro-inflammatory milieu in the presence versus immunosuppressive milieu (with increased interleukin-10) in the absence of microbiome. Collectively, microbiome abrogates the immunosuppressive response to UV by modulating gene expression and cellular microenvironment of the skin. Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.