Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lourenço, AP; Leite-Moreira, AF; Balligand, JL; Bauersachs, J; Dawson, D; de Boer, RA; de Windt, LJ; Falcão-Pires, I; Fontes-Carvalho, R; Franz, S; Giacca, M; Hilfiker-Kleiner, D; Hirsch, E; Maack, C; Mayr, M; Pieske, B; Thum, T; Tocchetti, CG; Brutsaert, DL; Heymans, S.
An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.
Eur J Heart Fail. 2018; 20(2):216-227
Doi: 10.1002/ejhf.1059
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF. © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cardiology -
- Consensus -
- Europe -
- Heart Failure - physiopathology
- Humans -
- Myocardial Contraction - physiology
- Societies, Medical -
- Stroke Volume - physiology
- Ventricular Function, Left - physiology
- Find related publications in this database (Keywords)
- Heart failure with preserved ejection fraction
- Animal models
- Experimental evaluation
- Molecular biology
- Myocardial function