Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bauer, J; Chen, W; Nischwitz, S; Liebl, J; Rieken, S; Welzel, T; Debus, J; Parodi, K.
Improving the modelling of irradiation-induced brain activation for in vivo PET verification of proton therapy.
Radiother Oncol. 2018; 128(1): 101-108.
Doi: 10.1016/j.radonc.2018.01.016
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Nischwitz Sebastian
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- Abstract:
- A reliable Monte Carlo prediction of proton-induced brain tissue activation used for comparison to particle therapy positron-emission-tomography (PT-PET) measurements is crucial for in vivo treatment verification. Major limitations of current approaches to overcome include the CT-based patient model and the description of activity washout due to tissue perfusion. Two approaches were studied to improve the activity prediction for brain irradiation: (i) a refined patient model using tissue classification based on MR information and (ii) a PT-PET data-driven refinement of washout model parameters. Improvements of the activity predictions compared to post-treatment PT-PET measurements were assessed in terms of activity profile similarity for six patients treated with a single or two almost parallel fields delivered by active proton beam scanning. The refined patient model yields a generally higher similarity for most of the patients, except in highly pathological areas leading to tissue misclassification. Using washout model parameters deduced from clinical patient data could considerably improve the activity profile similarity for all patients. Current methods used to predict proton-induced brain tissue activation can be improved with MR-based tissue classification and data-driven washout parameters, thus providing a more reliable basis for PT-PET verification. Copyright © 2018 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain - diagnostic imaging
- Brain Neoplasms - diagnostic imaging
- Brain Neoplasms - radiotherapy
- Humans -
- Models, Biological -
- Monte Carlo Method -
- Positron-Emission Tomography - methods
- Proton Therapy - methods
- Find related publications in this database (Keywords)
- Proton therapy
- PET verification
- In vivo verification
- Monte Carlo simulation
- Washout model