Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Renner, W; Nauck, M; Winkelmann, BR; Hoffmann, MM; Scharnagl, H; Mayer, V; Boehm, BO; März, W; LURIC Study team.
Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study.
J Mol Med (Berl). 2005; 83(3):235-239
Doi: 10.1007/s00109-004-0618-0
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- Führende Autor*innen der Med Uni Graz
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Scharnagl Hubert
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- Abstract:
- Angiotensinogen and its cleaved forms angiotensin I and angiotensin II are important regulators of blood pressure. The gene for angiotensinogen (AGT) carries two common polymorphisms, T207M and M268T (previously described as T174M and M235T). To investigate the role of haplotypes formed by these polymorphisms for angiotensinogen levels we examined blood pressure, coronary artery disease (CAD), myocardial infarction (MI), and AGT genotypes and haplotypes in 2,575 patients with angiographically documented CAD and 731 individuals in whom CAD had been ruled out by angiography. Three haplotypes, designated as Hap1 (T207, M268), Hap2 (T207, T268) and Hap3 (M207, T268), accounted for more than 99% of alleles. The AGT Hap2 haplotype was significantly associated with angiotensinogen levels; one additional Hap2 allele accounted for an approx. 8% increase in angiotensinogen. This association was stronger than that of either single polymorphism. AGT genotypes or haplotypes were not related to hypertension, CAD or MI. We conclude that a common haplotype of the angiotensinogen gene is linked to angiotensinogen levels but has no major impact on blood pressure, hypertension, or cardiovascular risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiotensinogen - blood Angiotensinogen - genetics
- Blood Pressure - genetics
- Coronary Artery Disease - genetics
- Female -
- Haplotypes - genetics
- Health -
- Homozygote -
- Humans -
- Male -
- Middle Aged -
- Polymorphism, Single Nucleotide - genetics
- Risk Factors -
- Find related publications in this database (Keywords)
- AGT gene
- angiotensinogen
- blood pressure
- coronary artery disease
- myocardial infarction