Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Trummer, C; Theiler-Schwetz, V; Kollmann, M; Wölfler, M; Heijboer, AC; Pilz, S; Obermayer-Pietsch, B.
Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.
Eur J Nutr. 2019; 58(8):3135-3146
Doi: 10.1007/s00394-018-1858-z
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- Kollmann Martina
- Obermayer-Pietsch Barbara
- Pilz Stefan
- Theiler-Schwetz Verena
- Trummer Christian
- Wölfler Monika Martina
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- Abstract:
- It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline. The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating hormone, luteinizing hormone, metabolic characteristics, and body composition. Ninety-four men [mean age and 25(OH)D: 47 (± 12) years and 56.3 (± 18.3) nmol/l, respectively] completed the study. We found no significant treatment effect on serum TT or on the remaining secondary outcome variables. Vitamin D treatment had no effect on serum TT levels in middle-aged healthy men with low TT levels.
- Find related publications in this database (Keywords)
- Vitamin D
- Testosterone
- Randomized controlled trial
- SHBG
- Androgens