Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Olivares, M; Schüppel, V; Hassan, AM; Beaumont, M; Neyrinck, AM; Bindels, LB; Benítez-Páez, A; Sanz, Y; Haller, D; Holzer, P; Delzenne, NM.
The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health.
Front Microbiol. 2018; 9(5):1900-1900
Doi: 10.3389/fmicb.2018.01900
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- Co-Autor*innen der Med Uni Graz
- Hassan Ahmed
- Holzer Peter
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- Abstract:
- The Dipeptidyl peptidase-4 (DPP-4) activity influences metabolic, behavioral and intestinal disorders through the cleavage of key hormones and peptides. Some studies describe the existence of human DPP-4 homologs in commensal bacteria, for instance in Prevotella or Lactobacillus. However, the role of the gut microbiota as a source of DPP-4-like activity has never been investigated. Through the comparison of the DPP-4 activity in the cecal content of germ-free mice (GFM) and gnotobiotic mice colonized with the gut microbiota of a healthy subject, we bring the proof of concept that a significant DPP-4-like activity occurs in the microbiota. By analyzing the existing literature, we propose that DPP-4-like activity encoded by the intestinal microbiome could constitute a novel mechanism to modulate protein digestion as well as host metabolism and behavior.
- Find related publications in this database (Keywords)
- DPP-4 activity
- PepX activity
- gut microbiota
- microbiome
- metabolism
- behavior