Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gürntke, S; Kohler, C; Steinmetz, I; Pfeifer, Y; Eller, C; Gastmeier, P; Schwab, F; Leistner, R.
Molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-positive Klebsiella pneumoniae from bloodstream infections and risk factors for mortality.
J Infect Chemother. 2014; 20(12): 817-819.
Doi: 10.1016/j.jiac.2014.08.012
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Steinmetz Ivo
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- Abstract:
- The prevalence of extended-spectrum beta-lactamase (ESBL)-positive Klebsiella pneumoniae is growing worldwide. Infections with these bacteria are suspected to be related to increased mortality. We aimed to estimate the distribution of ESBL genotypes and to assess the impact on mortality associated with ESBL positivity in cases of bloodstream infection (BSI) due to K. pneumoniae. We performed a cohort study on patients with K. pneumoniae BSI between 2008 and 2011. Presence of ESBL genes was analyzed by PCR and sequencing. Risk factors for mortality were analyzed by Cox-proportional hazard regression. We identified 286 ESBL-negative (81%) and 66 (19%) ESBL-positive cases. 97% (n = 64) of the ESBL-positive isolates were susceptible for meropenem. The most common ESBL genotypes were CTX-M-15 (60%), SHV-5 (27%) and CTX-M-3 (5%). Significant risk factors for mortality were chronic pulmonary disease (HR 1.747) and moderate/severe renal disease (HR 2.572). ESBL positivity was not associated with increased mortality. Copyright © 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Bacteremia - microbiology
- Female -
- Genotype -
- Genotype - epidemiology
- Humans -
- Klebsiella Infections - epidemiology
- Klebsiella Infections - microbiology
- Klebsiella pneumoniae - drug effects
- Klebsiella pneumoniae - enzymology
- Klebsiella pneumoniae - genetics
- Male -
- Middle Aged -
- Molecular Epidemiology -
- Proportional Hazards Models -
- Retrospective Studies -
- Risk Factors -
- beta-Lactamases - biosynthesis
- beta-Lactamases - genetics
- Find related publications in this database (Keywords)
- ESBL
- Klebsiella pneumoniae
- Molecular epidemiology
- Bloodstream infection