Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dominguez-Escrig, JL; Peyronnet, B; Seisen, T; Bruins, HM; Yuan, CY; Babjuk, M; Böhle, A; Burger, M; Compérat, EM; Gontero, P; Lam, T; MacLennan, S; Mostafid, H; Palou, J; van Rhijn, BWG; Sylvester, RJ; Zigeuner, R; Shariat, SF; Rouprêt, M.
Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer.
Eur Urol Focus. 2019; 5(2):224-241
Doi: 10.1016/j.euf.2017.09.015
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zigeuner Richard
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- Abstract:
- The oncological efficacy of routine lymphadenectomy (lymph node dissection [LND]) at the time of radical nephroureterectomy (RNU) remains controversial. To systematically review the available literature assessing the impact of LND in upper tract urothelial carcinoma (UTUC) patients. Embase, Medline, and Cochrane databases were searched for all studies comparing outcomes of patients undergoing RNU without LND versus any form of LND. We identified nine retrospective studies eligible for inclusion in this systematic review. We took cancer-specific survival (CSS) as the primary end point, and performed a narrative review and risk of bias assessment. Six studies compared outcomes of no LND versus LND. Three studies compared complete LND versus incomplete LND versus no LND. The incidence of pN+ in patients with high-stage (≥pT2) tumours ranged from 14.3% to 40%. Pre- and postoperative characteristics differed among the study groups, potentially biasing the results, as demonstrated by the risk of bias assessment, potentially favouring the LND group. Oncological outcomes such as cancer-specific, overall, recurrence-free, and metastasis-free survival were reviewed, demonstrating a survival benefit with LND in high-stage disease of the renal pelvis. Template-based and complete LND improves CSS in patients with high-stage (≥pT2) UTUC and reduces the risk of local recurrence. The impact of LND in ureteral tumours remains uncertain. Studies comparing radical nephroureterectomy with or without the removal of nodes (lymph node dissection [LND]) were analysed. LND improves survival in patients with high-stage disease of the renal pelvis, if it is performed according to an anatomical template-based approach. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- Recurrence
- Urothelial carcinoma
- Renal pelvis
- Ureter
- Survival
- Nodes
- Metastasis