Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lucovnik, M; Lackner, HK; Papousek, I; Schmid-Zalaudek, K; Schulter, G; Roessler, A; Moertl, MG.
Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings.
Hypertens Pregnancy. 2017; 36(3):276-281 Doi: 10.1080/10641955.2017.1364381
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Führende Autor*innen der Med Uni Graz: Lackner Helmut Karl
Co-Autor*innen der Med Uni Graz: Mörtl Manfred Georg; Rössler Andreas; Schmid-Zalaudek Karin
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Abstract:: OBJECTIVE: To examine systemic vascular resistance index (SVRI), asymmetric (ADMA) and symmetric dimethylarginine (SDMA) levels in preeclampsia at different gestations. METHODS: Twenty-four preeclamptic patients (14 at ≥ 34 weeks') and 72 matched healthy controls were included. SVRI was calculated from impedance cardiography measurements. ADMA and SDMA levels were determined using enzyme-linked immunosorbent assay. RESULTS: SVRI and SDMA were higher in preeclampsia overall, in early onset and late onset compared to controls. SVRI was correlated with ADMA and SDMA, respectively. CONCLUSIONS: Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors.
Find related publications in this database (using NLM MeSH Indexing): Adult - administration & dosage; Arginine - analogs & derivatives, blood; Case-Control Studies - administration & dosage; Female - administration & dosage; Humans - administration & dosage; Pre-Eclampsia - blood, physiopathology; Pregnancy - administration & dosage; Vascular Resistance - administration & dosage; Young Adult - administration & dosage
Find related publications in this database (Keywords): ADMA; case-control methodology; nitric oxide synthesis; preeclampsia; SDMA