Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nass, N; Walter, S; Jechorek, D; Weissenborn, C; Ignatov, A; Haybaeck, J; Sel, S; Kalinski, T.
High neuronatin (NNAT) expression is associated with poor outcome in breast cancer.
Virchows Arch. 2017; 471(1): 23-30.
Doi: 10.1007/s00428-017-2154-7
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- Neuronatin (NNAT) is a proteolipid involved in cation homeostasis especially in the developing brain. Its expression has been associated with the progression of lung cancer, glioblastoma, and neuroblastoma as well as glucose induced apoptosis in pancreatic cells. We performed a retrospective study of 148 breast cancer specimens for NNAT expression by immunohistochemistry to evaluate this protein as a prognostic marker for breast cancer. We found a high NNAT immunoreactivity score (by multivariate cox regression) to be an independent prognostic marker for relapse-free (hazard ratio HR = 3.55, p = 0.002) and overall survival (HR = 6.29, p < 0.001). However, NNAT expression was not associated with classical parameters such as hormone receptor expression (p = 0.86) or lymph node metastasis (p = 0.83). Additional independent risk factors in this study population were tumor size (≤2 cm; overall survival: HR = 0.36, p = 0.023; relapse-free survival: HR = 0.26, p < 0.01) and blood vessel infiltration (overall survival: HR = 0.34 p < 0.01). NNAT expression determined by immunohistochemistry might therefore become a helpful additional biomarker to identify high-risk breast cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Area Under Curve -
- Biomarkers, Tumor - analysis
- Breast Neoplasms - metabolism
- Breast Neoplasms - mortality
- Breast Neoplasms - pathology
- Disease-Free Survival -
- Female -
- Humans -
- Immunohistochemistry -
- Kaplan-Meier Estimate -
- Membrane Proteins - analysis
- Membrane Proteins - biosynthesis
- Middle Aged -
- Nerve Tissue Proteins - analysis
- Nerve Tissue Proteins - biosynthesis
- Prognosis -
- Proportional Hazards Models -
- ROC Curve -
- Retrospective Studies -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- Breast cancer
- Neuronatin
- Immunohistochemistry
- Prognosis