Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Papousek, I; Weiss, EM; Mosbacher, JA; Reiser, EM; Schulter, G; Fink, A.
Affective processing in positive schizotypy: Loose control of social-emotional information.
Brain Cogn. 2014; 92C(50):84-91
Doi: 10.1016/j.bandc.2014.10.008
Web of Science
PubMed
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- Mosbacher Jochen
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- Abstract:
- Behavioral studies suggested heightened impact of emotionally laden perceptual input in schizophrenia spectrum disorders, in particular in patients with prominent positive symptoms. De-coupling of prefrontal and posterior cortices during stimulus processing, which is related to loosening of control of the prefrontal cortex over incoming affectively laden information, may underlie this abnormality. Pre-selected groups of individuals with low versus high positive schizotypy (lower and upper quartile of a large screening sample) were tested. During exposure to auditory displays of strong emotions (anger, sadness, cheerfulness), individuals with elevated levels of positive schizotypal symptoms showed lesser prefrontal-posterior coupling (EEG coherence) than their symptom-free counterparts (right hemisphere). This applied to negative emotions in particular and was most pronounced during confrontation with anger. The findings indicate a link between positive symptoms and a heightened impact particularly of threatening emotionally laden stimuli which might lead to exacerbation of positive symptoms and inappropriate behavior in interpersonal situations. Copyright © 2014 Elsevier Inc. All rights reserved.
- Find related publications in this database (Keywords)
- Schizotypy
- Schizotypal
- Functional connectivity
- EEG coherence
- Top-down modulation
- Social-emotional stimulation