Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Czapiewski, P; Bobowicz, M; Pęksa, R; Skrzypski, M; Gorczyński, A; Szczepańska-Michalska, K; Korwat, A; Jankowski, M; Zegarski, W; Szulgo-Paczkowska, A; Polec, T; Piątek, M; Skokowski, J; Haybaeck, J; Żaczek, A; Biernat, W.
Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma.
Pol J Pathol. 2017; 67(3):228-234
Doi: 10.5114/pjp.2016.63774
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- Co-Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide. Alterations in keratin expression, including keratin 7 (K7), are frequent findings in multiple cancers, and they constitute a prognostic factor. The aim of our study was to evaluate the prognostic significance of K7 in the primary tumour and lymph node metastases in two separate cohorts of patients: the first one with lymph node involvement (LN+, 129 cases) and the second one free of LN metastases (LN-, 85 cases). Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN- group. K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival. We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - mortality
- Adenocarcinoma - pathology
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - analysis
- Colorectal Neoplasms - mortality
- Colorectal Neoplasms - pathology
- Disease-Free Survival -
- Female -
- Humans -
- Immunohistochemistry -
- Kaplan-Meier Estimate -
- Keratin-7 - analysis
- Keratin-7 - biosynthesis
- Lymphatic Metastasis - pathology
- Male -
- Middle Aged -
- Prognosis -
- Proportional Hazards Models -
- Tissue Array Analysis -
- Find related publications in this database (Keywords)
- keratin 7
- metastasis
- colon carcinoma
- prognosis
- lymph node metastases