Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cerk, S; Schwarzenbacher, D; Adiprasito, JB; Stotz, M; Hutterer, GC; Gerger, A; Ling, H; Calin, GA; Pichler, M.
Current Status of Long Non-Coding RNAs in Human Breast Cancer.
Int J Mol Sci. 2016; 17(9):
Doi: 10.3390/ijms17091485
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- Führende Autor*innen der Med Uni Graz
- Cerk Stefanie Anna
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Adiprasito Jan Basri
- Gerger Armin
- Hutterer Georg
- Ninaus Daniela
- Stotz Michael
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- Abstract:
- Breast cancer represents a major health burden in Europe and North America, as recently published data report breast cancer as the second leading cause of cancer related death in women worldwide. Breast cancer is regarded as a highly heterogeneous disease in terms of clinical course and biological behavior and can be divided into several molecular subtypes, with different prognosis and treatment responses. The discovery of numerous non-coding RNAs has dramatically changed our understanding of cell biology, especially the pathophysiology of cancer. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts >200 nucleotides in length. Several studies have demonstrated their role as key regulators of gene expression, cell biology and carcinogenesis. Deregulated expression levels of lncRNAs have been observed in various types of cancers including breast cancer. lncRNAs are involved in cancer initiation, progression, and metastases. In this review, we summarize the recent literature to highlight the current status of this class of long non-coding lncRNAs in breast cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor - genetics
- Biomarkers, Tumor - metabolism
- Breast Neoplasms - genetics
- Breast Neoplasms - metabolism
- Breast Neoplasms - pathology
- Carcinoma - genetics
- Carcinoma - metabolism
- Carcinoma - pathology
- Female -
- Gene Expression Regulation, Neoplastic -
- Humans -
- RNA, Long Noncoding - genetics
- RNA, Long Noncoding - metabolism
- Find related publications in this database (Keywords)
- breast cancercarcinoma
- long non-coding RNA
- oncogene
- tumor suppressor