Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Barghash, A; Golob-Schwarzl, N; Helms, V; Haybaeck, J; Kessler, SM.
Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma.
Oncotarget. 2016; 7(31):49743-49750
Doi: 10.18632/oncotarget.10439
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- Führende Autor*innen der Med Uni Graz
- Kessler Sonja
- Co-Autor*innen der Med Uni Graz
- Golob-Schwarzl Nicole
- Haybäck Johannes
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- Abstract:
- Esophageal adenocarcinoma (EAC) represents the sixth leading cause of cancer-related deaths and develops in Barret's esophagus affected tissues. The IGF2 mRNA binding protein IMP2/IGF2BP2/p62 was originally identified as an autoantigen in hepatocellular carcinoma. Aim of this study was to investigate the expression and prognostic role of IMP2 in EAC. Human EAC and Barret's esophagus tissue showed overexpression of IMP2, particularly in tumors of increased size and in metastatic tissues. Molecular classification based on published gene signatures of esophageal cancer revealed a specific subtype, in which the expression of IMP2 is high. According to GO and KEGG pathway analyses, genes showing highly correlated expression with IMP2 are associated with growth, proliferation, metabolism, inflammation, and cancerous processes. Clustering of EAC samples according to published survival marker genes strongly suggests that IMP2 overexpressing samples show poor survival. Finally, IMP2 expression correlated with short survival in patients with EAC or esophageal squamous carcinoma. Our data indicate that IMP2 might be a useful prognostic marker for Barret's esophagus and EAC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - metabolism
- Adenocarcinoma - mortality
- Esophageal Neoplasms - metabolism
- Esophageal Neoplasms - mortality
- Gene Expression Profiling -
- Gene Expression Regulation, Neoplastic -
- Genome, Human -
- Humans -
- Immunohistochemistry -
- Inflammation -
- Neoplasm Metastasis -
- Oligonucleotide Array Sequence Analysis -
- Prognosis -
- RNA, Messenger - metabolism
- RNA-Binding Proteins - metabolism
- Signal Transduction -
- Tissue Array Analysis -
- Find related publications in this database (Keywords)
- IGF2BP2/IMP2/p62
- barret's esophagus
- esophageal squamous carcinoma
- esophageal adenocarcinoma
- metastasis