Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Huber, R; Grittner, U; Weidemann, F; Thijs, V; Tanislav, C; Enzinger, C; Fazekas, F; Wolf, M; Hennerici, MG; McCabe, DJ; Putaala, J; Tatlisumak, T; Kessler, C; von Sarnowski, B; Martus, P; Kolodny, E; Norrving, B; Rolfs, A; Stroke in Young Fabry Patients (SIFAP) Investigators.
Patent Foramen Ovale and Cryptogenic Strokes in the Stroke in Young Fabry Patients Study.
Stroke. 2017; 48(1):30-35
Doi: 10.1161/STROKEAHA.116.013620
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- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
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- Abstract:
- A patent foramen ovale (PFO) is disproportionately prevalent in patients with cryptogenic stroke. Without alternative explanations, it is frequently considered to be causative. A detailed stratification of these patients may improve the identification of incidental PFO. We investigated the PFO prevalence in 3497 transient ischemic attack and ischemic stroke patients aged 18 to 55 years in the prospective multicenter SIFAP1 study (Stroke in Young Fabry Patients 1) using the ASCO classification. Patients without an obvious cause for transient ischemic attack/stroke (ASCO 0) were divided into subgroups with and without vascular risk factors (ASCO 0+ and 0-). In addition, we looked for PFO-related magnetic resonance imaging lesion patterns. PFO was identified in 25% of patients. Twenty percent of patients with a definite or probable cause of transient ischemic attack/stroke (≥1 grade 1 or 2 ASCO criterion; n=1769) had a PFO compared with 29% of cryptogenic stroke patients (ASCO 0 and 3; n=1728; P<0,001); subdivision of cryptogenic strokes revealed a PFO in 24% of 978 ASCO 3 patients (n.s. versus ASCO 1 and 2) and a higher prevalence of 36% in 750 ASCO 0 cases (P<0.001 versus ASCO 3 and versus ASCO 1 and 2). PFO was more commonly observed in ASCO 0- (n=271) than in ASCO 0+ patients (n=479; 48 versus 29%; P<0.001). There was no PFO-associated magnetic resonance imaging lesion pattern. Cryptogenic stroke patients demonstrate a heterogeneous PFO prevalence. Even in case of less conclusive diseases like nonstenotic arteriosclerosis, patients should preferentially be considered to have a non-PFO-mediated stroke. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00414583. © 2016 American Heart Association, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Fabry Disease - diagnostic imaging
- Fabry Disease - epidemiology
- Female -
- Foramen Ovale, Patent - diagnostic imaging
- Foramen Ovale, Patent - epidemiology
- Humans -
- Ischemic Attack, Transient - diagnostic imaging
- Ischemic Attack, Transient - epidemiology
- Male -
- Middle Aged -
- Prospective Studies -
- Stroke - diagnostic imaging
- Stroke - epidemiology
- Young Adult -
- Find related publications in this database (Keywords)
- arteriosclerosis
- ischemic stroke
- MRI
- patent foramen ovale
- risk factors