Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Senft, JD; Gotthardt, DN; Frischbier, L; Bruns, H; Schemmer, P.
A Retrospective Comparison of Mycophenolate Mofetil with Low-Exposure Cyclosporine Versus Standard Cyclosporine Therapy in De Novo Liver Transplant Patients.
Ann Transplant. 2015; 20(5):539-543
Doi: 10.12659/AOT.894078
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- Führende Autor*innen der Med Uni Graz
- Schemmer Peter
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- Abstract:
- BACKGROUND Data on low-exposure calcineurin inhibitor therapy with mycophenolate mofetil (MMF) in de novo liver transplant patients are limited and restricted to tacrolimus. MATERIAL AND METHODS Twenty-eight patients receiving cyclosporine and MMF at a single center were identified retrospectively and categorized as low-exposure or standard-exposure CsA (median concentration <80 ng/mL [n=16] or ≥80 ng/mL [n=12] during days 1-7) and analyzed to 12 weeks post-transplant. RESULTS Biopsy-proven acute rejection (Banff ≥4) occurred in 3 low-CsA patients and no standard-CsA patients (p=0.238); graft failure occurred in 4 and zero patients, respectively (p=0.113); no graft loss was attributable to rejection. Mean (SD) estimated GFR at baseline and week 12 was 79.5 (45.3) and 79.3 (24.5) mL/min/1.73 m2 in the low-CsA group (p=0.508), and 106.0 (66.9) and 86.7 (23.2) mL/min/1.73 m2 in the standard-CsA group (p=0.093). Estimated GFR decreased significantly in patients with good baseline renal function (≥80 mL/min/1.73 m2) in the standard-CsA (p=0.028) and increased markedly in patients with poor function (≤60 mL/min/1.73 m2) given low-CsA (p=0.043). There was no significant between-group difference regarding incidence of infections. CONCLUSIONS These preliminary findings suggest that immunosuppressive efficacy is maintained with low-exposure CsA and MMF in de novo liver transplant patients and good baseline renal function may be better preserved, but no benefit for infections was observed.
- Find related publications in this database (using NLM MeSH Indexing)
- Cyclosporine - therapeutic use
- Drug Therapy, Combination -
- Female -
- Graft Rejection - prevention & control
- Humans -
- Immunosuppressive Agents - administration & dosage
- Immunosuppressive Agents - therapeutic use
- Liver Transplantation - methods
- Male -
- Middle Aged -
- Mycophenolic Acid - analogs & derivatives
- Mycophenolic Acid - therapeutic use
- Retrospective Studies -
- Find related publications in this database (Keywords)
- Cyclosporine
- Immunosuppressive Agents
- Liver Transplantation