Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ranzinger, J; Rustom, A; Heide, D; Morath, C; Schemmer, P; Nawroth, PP; Zeier, M; Schwenger, V.
The receptor for advanced glycation end-products (RAGE) plays a key role in the formation of nanotubes (NTs) between peritoneal mesothelial cells and in murine kidneys.
Cell Tissue Res. 2014; 357(3):667-679
Doi: 10.1007/s00441-014-1904-y
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Schemmer Peter
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- Abstract:
- The receptor for advanced glycation end-products (RAGE), a multiligand receptor of the immunoglobulin superfamily, takes part in various inflammatory processes. The role of this receptor in the context of intercellular communication, like nanotube (NT)-mediated interaction, is largely unknown. Here, we use cell cultures of human and murine peritoneal mesothelial cells as well as murine kidneys from wild-type and RAGE knockout mouse models to assess the role of RAGE in NT formation and function. We show that loss of RAGE function results in reduced NT numbers under physiological conditions and demonstrate the involvement of MAP kinase signaling in NT formation. Additionally, we show for the first time the existence of NTs in murine kidney tissue and confirm the correlation of RAGE expression and NT numbers. Under elevated oxidative stress conditions like renal ischemia or peritoneal dialysis, we demonstrate that RAGE absence does not prevent NT formation. Rather, increased NT numbers and attenuated kidney tissue damage could be observed, indicating that, depending on the predominant conditions, RAGE affects NT formation with implications for cellular communication.
- Find related publications in this database (using NLM MeSH Indexing)
- Advanced Glycosylation End Product-Specific Receptor -
- Animals -
- Disease Models, Animal -
- Epithelial Cells - drug effects
- Epithelial Cells - metabolism
- Glucose - pharmacology
- Humans -
- Kidney - drug effects
- Kidney - metabolism
- Kidney - pathology
- Mice, Inbred C57BL -
- Mice, Knockout -
- Nanotubes - chemistry
- Osmolar Concentration -
- Oxidative Stress - drug effects
- Peritoneal Cavity - cytology
- Receptors, Immunologic - metabolism
- Reperfusion Injury - pathology
- p38 Mitogen-Activated Protein Kinases - metabolism
- Find related publications in this database (Keywords)
- Mesothelial cells
- RAGE
- Nanotubes
- Oxidative stress
- Kidney