Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Salnikov, AV; Kusumawidjaja, G; Rausch, V; Bruns, H; Gross, W; Khamidjanov, A; Ryschich, E; Gebhard, MM; Moldenhauer, G; Büchler, MW; Schemmer, P; Herr, I.
Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter.
Cancer Lett. 2009; 275(2):185-193
Doi: 10.1016/j.canlet.2008.10.015
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Schemmer Peter
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- Abstract:
- Recent findings suggest that the presence of cancer stem cells could be linked with patients' survival. We profiled suggested cancer stem cell markers in tissue specimens of hepatocellular carcinoma and colorectal carcinoma liver metastases. About 1% of cells co-expressed cancer stem cell antigens, but there was no correlation between the amount of CD133(+), CD133(+)/CD44(+) or CD133(+)/CD24(-) cells and the patients' clinical-pathological status or with the cancer stem cell marker-positive cells localization. CD133(+) and CD133(-) fractions of Huh7 cells did not differ in migratory properties. Therefore, presence of markers alone should be taken with caution as single prognostic parameters.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, CD - metabolism
- Biomarkers, Tumor - metabolism
- Carcinoma, Hepatocellular - metabolism
- Carcinoma, Hepatocellular - pathology
- Carcinoma, Hepatocellular - secondary
- Colorectal Neoplasms - pathology
- Female -
- Fluorescent Antibody Technique -
- Humans -
- Immunophenotyping -
- Liver Neoplasms - metabolism
- Liver Neoplasms - pathology
- Liver Neoplasms - secondary
- Male -
- Middle Aged -
- Neoplastic Stem Cells - immunology
- Neoplastic Stem Cells - metabolism
- Prognosis -
- Find related publications in this database (Keywords)
- Cancer stem cells
- Tumour-initiating cells
- Hepatocellular carcinoma
- Colorectal carcinoma
- Migration