Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moser, G; Weiss, G; Sundl, M; Gauster, M; Siwetz, M; Lang-Olip, I; Huppertz, B.
Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins.
Histochem Cell Biol. 2017; 147(3):353-366
Doi: 10.1007/s00418-016-1509-5
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- Führende Autor*innen der Med Uni Graz
- Moser Gerit
- Co-Autor*innen der Med Uni Graz
- Gauster Martin
- Huppertz Berthold
- Lang-Olip Ingrid
- Siwetz Monika
- Sundl Monika
- Weiss Gregor
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- Abstract:
- During the first trimester of pregnancy, extravillous trophoblasts (EVTs) invade into the decidual interstitium to the first third of the myometrium, thereby anchoring the placenta to the uterus. They also follow the endovascular and endoglandular route of invasion; plug, line and remodel spiral arteries, thus being responsible for the establishment of hemotrophic nutrition with the beginning of the second trimester and invade and open uterine glands toward the intervillous space for a histiotrophic nutrition during the first trimester. The aim of this study was to provide proof that uterine veins are invaded by EVTs similar to uterine arteries and glands in first trimester of pregnancy. Therefore, serial sections from in situ first trimester placenta were immuno-single- and immuno-double-stained to distinguish in a first step between arteries and veins and secondly between invaded and non-invaded vessels. Subsequently, invasion of EVTs into uterine vessels was quantified. Our data show that uterine veins are significantly more invaded by EVTs than uterine arteries (29.2 ± 15.7 %) during early pregnancy. Counted vessel cross sections revealed significantly higher EVT invasion into veins (59.5 ± 7.9 %) compared to arteries (29.2 ± 15.7 %). In the lumen of veins, single EVTs were repeatedly found, beside detached glandular epithelial cells or syncytial fragments. This study allows the expansion of our hitherto postulated concept of EVT invasion during first trimester of pregnancy. We suggest that invasion of EVTs into uterine veins is responsible the draining of waste and blood plasma from the intervillous space during the first trimester of pregnancy.
- Find related publications in this database (using NLM MeSH Indexing)
- Female -
- Humans -
- Immunohistochemistry -
- Pregnancy -
- Pregnancy Trimester, First -
- Trophoblasts - cytology
- Trophoblasts - metabolism
- Uterine Artery - cytology
- Uterine Artery - metabolism
- Uterus - blood supply
- Veins - cytology
- Veins - metabolism
- Find related publications in this database (Keywords)
- Extravillous trophoblasts
- Endovascular trophoblasts
- Endoglandular trophoblasts
- Uterine veins
- Invasion
- Placenta