Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Czapiewski, P; Gorczynski, A; Radecka, K; Wiewiora, C; Haybaeck, J; Adam, P; Fend, F; Zakrzewska, M; Zakrzewski, K; Liberski, PP; Biernat, W.
Expression of SOX11, PAX5, TTF-1 and ISL-1 in medulloblastoma.
Pathol Res Pract. 2016; 212(11):965-971
Doi: 10.1016/j.prp.2016.08.006
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- The aim of our study was to evaluate the immunohistochemical expression of SOX11, PAX5, TTF-1 and ISL-1 in medulloblastoma (MB) to investigate their diagnostic usefulness. Immunohistochemical expression of PAX5 (two antibodies: Dako, DAK-Pax5; and BD, clone 24), TTF-1 (Dako, 8G7G3/1), SOX11 (CL0142; Abcam) and ISL-1 (1 H9, Abcam) was analyzed using the h-score and Remmele score in 25 cases of MB. There were 18 MBs of classic and 7 of desmoplastic type. SOX11 was strongly expressed in all tumors. The expression of PAX5 was higher and more frequent in a case of DAK-Pax5 clone (25/25) than clone 24 (6/25). ISL-1 was positive in 11 (44%) and TTF-1 in 3 (12%) cases. ISL-1 expression correlated positively (p<0.001), while TTF-1 correlated negatively with the age of patients (p=0.039). PAX5 expression correlated with ISL-1 (p=0.039) and showed a trend toward higher expression in the desmoplastic subtype (p=0.069). SOX11 is strongly and robustly expressed in MBs. PAX5 expression pattern differs substantially among two antibody clones. TTF-1 and ISL-1 is associated with the age of patients. Copyright © 2016 Elsevier GmbH. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Biomarkers, Tumor - analysis
- Cerebellar Neoplasms - diagnosis
- Cerebellar Neoplasms - metabolism
- Child -
- Child, Preschool -
- DNA-Binding Proteins - analysis
- DNA-Binding Proteins - biosynthesis
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- Humans -
- Immunohistochemistry -
- Infant -
- LIM-Homeodomain Proteins - analysis
- LIM-Homeodomain Proteins - biosynthesis
- Male -
- Medulloblastoma - diagnosis
- Medulloblastoma - metabolism
- PAX5 Transcription Factor - analysis
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- SOXC Transcription Factors - analysis
- SOXC Transcription Factors - biosynthesis
- Transcription Factors - analysis
- Transcription Factors - biosynthesis
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- Find related publications in this database (Keywords)
- SOX11
- PAX5
- TTF-1
- ISL-1
- Medulloblastoma