Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Czapiewski, P; Gorczyński, A; Haybaeck, J; Okoń, K; Reszeć, J; Skrzypczak, W; Dzierżanowski, J; Kunc, M; Karczewska, J; Biernat, W.
Expression pattern of ISL-1, TTF-1 and PAX5 in olfactory neuroblastoma.
Pol J Pathol. 2016; 67(2):130-135
Doi: 10.5114/PJP.2016.61448
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- Co-Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs. We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated. TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63.64%, h-score: 23-200), and in 3/11 cases (27.77%, h-score 3-85), respectively. The patient with the strongest PAX5 reactivity exhibited an aggressive clinical course with rapid dissemination to the spine and death shortly after the diagnosis. No significant correlation in the expression of PAX5 and TTF-1 ( = 0.43; p = 0.18) was observed. ISL-1 is widely expressed in tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis. TTF-1 positivity does not exclude the diagnosis of primary ONB, although usually only a small percentage of cells are positive. PAX5 expression is infrequent (27.27%) in ONB; however, if present it can be associated with a very aggressive clinical course.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - analysis
- DNA-Binding Proteins - analysis
- DNA-Binding Proteins - biosynthesis
- Esthesioneuroblastoma, Olfactory - metabolism
- Esthesioneuroblastoma, Olfactory - pathology
- Female -
- Humans -
- Immunohistochemistry -
- LIM-Homeodomain Proteins - analysis
- LIM-Homeodomain Proteins - biosynthesis
- Male -
- Middle Aged -
- Nasal Cavity - pathology
- Nose Neoplasms - metabolism
- Nose Neoplasms - pathology
- PAX5 Transcription Factor - analysis
- PAX5 Transcription Factor - biosynthesis
- Transcription Factors - analysis
- Transcription Factors - biosynthesis
- Young Adult -
- Find related publications in this database (Keywords)
- olfactory neuroblastoma
- esthesioneuroblastoma
- ISL-1
- TTF-1
- PAX5