Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Czapiewski, P; Kunc, M; Haybaeck, J.
Genetic and molecular alterations in olfactory neuroblastoma: implications for pathogenesis, prognosis and treatment.
Oncotarget. 2016; 7(32):52584-52596
Doi: 10.18632/oncotarget.9683
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- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- Olfactory neuroblastoma (ONB, Esthesioneuroblastoma) is an infrequent neoplasm of the head and neck area derived from olfactory neuroepithelium. Despite relatively good prognosis a subset of patients shows recurrence, progression and/or metastatic disease, which requires additional treatment. However, neither prognostic nor predictive factors are well specified. Thus, we performed a literature search for the currently available data on disturbances in molecular pathways, cytogenetic changes and results gained by next generation sequencing (NGS) approaches in ONB in order to gain an overview of genetic alterations which might be useful for treating patients with ONB. We present briefly ONB molecular pathogenesis and propose potential therapeutic targets and prognostic factors. Possible therapeutic targets in ONB include: receptor tyrosine kinases (c-kit, PDGFR-b, TrkB; EGFR); somatostatin receptor; FGF-FGFR1 signaling; Sonic hedgehog pathway; apoptosis-related pathways (Bcl-2, TRAIL) and neoangiogenesis (VEGF; KDR). Furthermore, we compare high- and low-grade ONB, and describe its frequent mimicker: sinonasal neuroendocrine carcinoma. ONB is often a therapeutic challenge, so our goal should be the implementation of acquired knowledge into clinical practice, especially at pretreated, recurrent and metastatic stages. Moreover, the multicenter molecular studies are needed to increase the amount of available data.
- Find related publications in this database (using NLM MeSH Indexing)
- Esthesioneuroblastoma, Olfactory - genetics
- Esthesioneuroblastoma, Olfactory - pathology
- Humans -
- Nasal Cavity - pathology
- Nose Neoplasms - genetics
- Nose Neoplasms - pathology
- Prognosis -
- Find related publications in this database (Keywords)
- olfactory neuroblastoma
- esthesioneuroblastoma
- mutation
- comparative genomic hybridization
- next generation sequencing