Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cashman, KD; Dowling, KG; Škrabáková, Z; Gonzalez-Gross, M; Valtueña, J; De Henauw, S; Moreno, L; Damsgaard, CT; Michaelsen, KF; Mølgaard, C; Jorde, R; Grimnes, G; Moschonis, G; Mavrogianni, C; Manios, Y; Thamm, M; Mensink, GB; Rabenberg, M; Busch, MA; Cox, L; Meadows, S; Goldberg, G; Prentice, A; Dekker, JM; Nijpels, G; Pilz, S; Swart, KM; van Schoor, NM; Lips, P; Eiriksdottir, G; Gudnason, V; Cotch, MF; Koskinen, S; Lamberg-Allardt, C; Durazo-Arvizu, RA; Sempos, CT; Kiely, M.
Vitamin D deficiency in Europe: pandemic?
Am J Clin Nutr. 2016; 103(4):1033-1044
Doi: 10.3945/ajcn.115.120873
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Pilz Stefan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH)D values from national health/nutrition surveys. This study applied VDSP protocols to serum 25(OH)D data from representative childhood/teenage and adult/older adult European populations, representing a sizable geographical footprint, to better quantify the prevalence of vitamin D deficiency in Europe. The VDSP protocols were applied in 14 population studies [reanalysis of subsets of serum 25(OH)D in 11 studies and complete analysis of all samples from 3 studies that had not previously measured it] by using certified liquid chromatography-tandem mass spectrometry on biobanked sera. These data were combined with standardized serum 25(OH)D data from 4 previously standardized studies (for a total n= 55,844). Prevalence estimates of vitamin D deficiency [using various serum 25(OH)D thresholds] were generated on the basis of standardized 25(OH)D data. An overall pooled estimate, irrespective of age group, ethnic mix, and latitude of study populations, showed that 13.0% of the 55,844 European individuals had serum 25(OH)D concentrations <30 nmol/L on average in the year, with 17.7% and 8.3% in those sampled during the extended winter (October-March) and summer (April-November) periods, respectively. According to an alternate suggested definition of vitamin D deficiency (<50 nmol/L), the prevalence was 40.4%. Dark-skinned ethnic subgroups had much higher (3- to 71-fold) prevalence of serum 25(OH)D <30 nmol/L than did white populations. Vitamin D deficiency is evident throughout the European population at prevalence rates that are concerning and that require action from a public health perspective. What direction these strategies take will depend on European policy but should aim to ensure vitamin D intakes that are protective against vitamin D deficiency in the majority of the European population. © 2016 American Society for Nutrition.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Child -
- Child, Preschool -
- Chromatography, Liquid -
- Databases, Factual -
- Europe - epidemiology
- Female -
- Humans -
- Infant -
- Male -
- Middle Aged -
- Nutrition Surveys -
- Nutritional Status -
- Pandemics -
- Prevalence -
- Seasons -
- Tandem Mass Spectrometry -
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Vitamin D Deficiency - blood
- Vitamin D Deficiency - epidemiology
- Vitamin D Deficiency - ethnology
- Young Adult -
- Find related publications in this database (Keywords)
- vitamin D deficiency
- prevalence
- 25(OH)D
- standardized
- Europe