Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zimmermann, FA; Mayr, JA; Feichtinger, R; Neureiter, D; Lechner, R; Koegler, C; Ratschek, M; Rusmir, H; Sargsyan, K; Sperl, W; Kofler, B.
Respiratory chain complex I is a mitochondrial tumor suppressor of oncocytic tumors.
Front Biosci (Elite Ed). 2011; 3:315-325
Doi: 10.2741/e247
PubMed
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- Co-Autor*innen der Med Uni Graz
- Ratschek Manfred
- Sargsyan Karine
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- Abstract:
- Oncocytic tumors, also called oxyphilic tumors, are characterized by hyperproliferation of mitochondria, which histologically presents as a fine granular eosinophilic cytoplasm. In accordance with the high mitochondrial density in oncocytomas, transcript levels of subunits of complexes of the oxidative phosphorylation (OXPHOS) system are increased. Hence, for a long time oncocytomas were presumed to have a highly active aerobic mitochondrial energy metabolism. Recently, detailed analysis of all OXPHOS complexes in a variety of oncocytomas revealed loss of complex I and compensatory up-regulation of the other complexes. In half of the oncocytoma cases examined the absence of complex I is caused by disruptive mutations in mitochondrial DNA encoding complex I subunits. The new data presented here on rare oncocytomas and the accompanying review of the literature clearly indicate that complex I deficiency in combination with up-regulation of mitochondria can be regarded as a hallmark of oncocytic tumor cells. Therefore, complex I of the respiratory chain has to be added to the growing list of mitochondrial tumor suppressors.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma, Oxyphilic - metabolism
- Adenoma, Oxyphilic - pathology
- DNA, Mitochondrial - genetics
- Electron Transport Complex I - genetics
- Electron Transport Complex I - metabolism
- Energy Metabolism - physiology
- Humans -
- Immunohistochemistry -
- Mitochondria - genetics
- Mitochondria - physiology
- Oxidative Phosphorylation -
- Sequence Analysis, DNA -
- Tumor Suppressor Proteins - genetics
- Tumor Suppressor Proteins - metabolism
- Up-Regulation -