Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rommer, PS; Fuchs, D; Leblhuber, F; Schroth, R; Greilberger, M; Tafeit, E; Greilberger, J.
Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer's Disease.
Neurodegener Dis. 2016; 16(3-4):284-289
Doi: 10.1159/000441565
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Greilberger Joachim
- Co-Autor*innen der Med Uni Graz
- Tafeit Erwin
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- Abstract:
- The critical role of neuro-inflammation and oxidative stress in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD) has become evident. The aim of this study is to assess the influence of vitamin supplementation on parameters of oxidative stress, inflammation as well as on cognition in patients with AD and mild cognitive impairment. In our study, patients with cognitive impairment and healthy controls were enrolled. All patients were intended to receive vitamin supplementation (vitamin B1, B6, B12 and folic acid) for 3 months. Mini Mental State Examination (MMSE) and laboratory markers [carbonyl proteins (CPs), malondialdehyde, tryptophan (Trp), kynurenine (Kyn), neopterin, folic acid, vitamin B12 level] were assessed for patients and controls at baseline and after 3 months. After half of the patients had been treated for 3 months, analyses were performed resulting in 3 subgroups: healthy controls without supplementation (15 subjects, 11 females), patients with vitamin supplementation (17 subjects, 10 females) and patients without vitamin supplementation (16 subjects, 9 females; baseline values prior to supplementation). Age was significantly higher for the supplemented group (76.4 ± 6.7 years) compared to vitamin-naïve patients (63.3 ± 13.7 years; p < 0.01). The MMSE score was higher in the supplemented group (23.1 ± 4.8 vs. 20.3 ± 9.5) but did not reach significance. Levels of CPs were significantly higher in the vitamin-naïve patients (p < 0.05). Levels of Kyn and the Kyn/Trp ratio were significantly lower in vitamin-naïve patients compared to the supplemented group (p < 0.05). No significant difference was seen for the other markers. Vitamin supplementation leads to reduced levels of CPs in patients. Pearson's correlation coefficient shows a negative relation (r = -0.69) between CPs and MMSE. Future trials should assess whether CPs might be suitable markers for monitoring of demented patients. © 2015 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Alzheimer Disease - diet therapy
- Alzheimer Disease - epidemiology
- Alzheimer Disease - metabolism
- Alzheimer Disease - psychology
- Biomarkers - metabolism
- Cognitive Dysfunction - diet therapy
- Cognitive Dysfunction - epidemiology
- Cognitive Dysfunction - metabolism
- Cognitive Dysfunction - psychology
- Dietary Supplements -
- Discriminant Analysis -
- Female -
- Folic Acid - administration & dosage
- Folic Acid - metabolism
- Humans -
- Kynurenine - metabolism
- Male -
- Mental Status Schedule -
- Middle Aged -
- ROC Curve -
- Thiamine - administration & dosage
- Treatment Outcome -
- Tryptophan - metabolism
- Vitamin B 12 - administration & dosage
- Vitamin B 12 - metabolism
- Vitamin B 6 - administration & dosage
- Vitamin B Complex - administration & dosage
- Find related publications in this database (Keywords)
- Alzheimer's disease
- Biomarker
- Neurodegenerative disease
- Vitamin B supplementation
- Oxidative stress
- Carbonyl proteins