Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, MA; Pichler, M; Haybaeck, J; Gerger, A.
Genetic markers of recurrence in colorectal cancer.
Pharmacogenomics. 2015; 16(11):1315-1328
Doi: 10.2217/pgs.15.83
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Smolle Maria Anna
- Co-Autor*innen der Med Uni Graz
- Haybäck Johannes
- Pichler Martin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Colorectal cancer (CRC) worldwide belongs to one of the most frequent cancers affecting both genders. Surgery and 5-fluorouracil-based adjuvant chemotherapy are recommended for patients with high-risk stage II and stage III colon carcinoma. Mutations of genes encoding for specific proteins may have an impact on the time to recurrence. These proteins act over specific signaling pathways, are implicated in metabolic processes and regulate the cell cycle. Though many retrospective studies show strong associations between genetic mutations and the clinical outcome of patients with CRC, currently no validated biomarkers are used in clinical routine settings. Therefore, large prospective validation studies should be carried out in order to strengthen the position of genetic mutations in personalized treatment of patients with CRC.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biomarkers, Tumor - genetics
- Colorectal Neoplasms - genetics
- Genetic Markers -
- Humans -
- Polymorphism, Genetic - genetics
- Find related publications in this database (Keywords)
- biomarkers
- colorectal cancer
- genetic markers of recurrence
- polymorphisms
- prognosis