Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zelzer, S; Mangge, H; Pailer, S; Ainoedhofer, H; Kieslinger, P; Stojakovic, T; Scharnagl, H; Prüller, F; Weghuber, D; Datz, C; Haybaeck, J; Obermayer-Pietsch, B; Trummer, C; Gostner, J; Gruber, HJ.
Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats.
Int J Mol Sci. 2015; 16(5):11689-11698
Doi: 10.3390/ijms160511689
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Zelzer Sieglinde
- Co-Autor*innen der Med Uni Graz
- Ainödhofer Herwig
- Gruber Hans-Jürgen
- Haybäck Johannes
- Kieslinger Petra
- Obermayer-Pietsch Barbara
- Pailer Sabine
- Prüller Florian
- Scharnagl Hubert
- Stojakovic Tatjana
- Trummer Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL), malondialdehyde (MDA), 4-hydroxynonenal (HNE), the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions were shown by T3 levels, both under normal and high fat diet. Thyroid dysfunctions were accompanied by changes in calorie intake and body weight as well as in the lipid profile. In detail, hypothyroid rats showed significantly decreased oxLDL levels, whereas hyperthyroid rats showed significantly increased oxLDL levels. These effects were seen under high fat diet and were less pronounced with normal feeding. Taken together, we showed for the first time in female SD rats that only hyper-, but not hypothyroidism, is associated with high atherogenic oxidized LDL irrespective of normal or high-fat diet in Sprague Dawley rats.
- Find related publications in this database (using NLM MeSH Indexing)
- Aldehydes - blood
- Aldehydes - metabolism
- Animals -
- Body Weight -
- Diet, High-Fat -
- Female -
- Hyperthyroidism - blood
- Hyperthyroidism - metabolism
- Hyperthyroidism - physiopathology
- Hypothyroidism - blood
- Hypothyroidism - metabolism
- Hypothyroidism - physiopathology
- Lipid Metabolism -
- Lipids - blood
- Lipoproteins, LDL - blood
- Lipoproteins, LDL - metabolism
- Malondialdehyde - blood
- Malondialdehyde - metabolism
- Rats -
- Rats, Sprague-Dawley -
- Thyroid Gland - metabolism
- Thyroid Gland - physiopathology
- Find related publications in this database (Keywords)
- hyperthyroidism
- oxidized LDL
- hypothyroidism
- fat feeding
- metabolic dysfunction
- Sprague Dawley rats