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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Zelzer, S; Mangge, H; Pailer, S; Ainoedhofer, H; Kieslinger, P; Stojakovic, T; Scharnagl, H; Prüller, F; Weghuber, D; Datz, C; Haybaeck, J; Obermayer-Pietsch, B; Trummer, C; Gostner, J; Gruber, HJ.
Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats.
Int J Mol Sci. 2015; 16(5):11689-11698 Doi: 10.3390/ijms160511689 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Mangge Harald
Zelzer Sieglinde
Co-Autor*innen der Med Uni Graz
Ainödhofer Herwig
Gruber Hans-Jürgen
Haybäck Johannes
Kieslinger Petra
Obermayer-Pietsch Barbara
Pailer Sabine
Prüller Florian
Scharnagl Hubert
Stojakovic Tatjana
Trummer Christian
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Abstract:
Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL), malondialdehyde (MDA), 4-hydroxynonenal (HNE), the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions were shown by T3 levels, both under normal and high fat diet. Thyroid dysfunctions were accompanied by changes in calorie intake and body weight as well as in the lipid profile. In detail, hypothyroid rats showed significantly decreased oxLDL levels, whereas hyperthyroid rats showed significantly increased oxLDL levels. These effects were seen under high fat diet and were less pronounced with normal feeding. Taken together, we showed for the first time in female SD rats that only hyper-, but not hypothyroidism, is associated with high atherogenic oxidized LDL irrespective of normal or high-fat diet in Sprague Dawley rats.
Find related publications in this database (using NLM MeSH Indexing)
Aldehydes - blood
Aldehydes - metabolism
Animals -
Body Weight -
Diet, High-Fat -
Female -
Hyperthyroidism - blood
Hyperthyroidism - metabolism
Hyperthyroidism - physiopathology
Hypothyroidism - blood
Hypothyroidism - metabolism
Hypothyroidism - physiopathology
Lipid Metabolism -
Lipids - blood
Lipoproteins, LDL - blood
Lipoproteins, LDL - metabolism
Malondialdehyde - blood
Malondialdehyde - metabolism
Rats -
Rats, Sprague-Dawley -
Thyroid Gland - metabolism
Thyroid Gland - physiopathology

Find related publications in this database (Keywords)
hyperthyroidism
oxidized LDL
hypothyroidism
fat feeding
metabolic dysfunction
Sprague Dawley rats
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