Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leygraf, A; Hohoff, C; Freitag, C; Willis-Owen, SA; Krakowitzky, P; Fritze, J; Franke, P; Bandelow, B; Fimmers, R; Flint, J; Deckert, J.
Rgs 2 gene polymorphisms as modulators of anxiety in humans?
J Neural Transm. 2006; 113(12):1921-1925
Doi: 10.1007/s00702-006-0484-8
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- Co-Autor*innen der Med Uni Graz
- Krakowitzky Petra
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- Abstract:
- Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.
- Find related publications in this database (using NLM MeSH Indexing)
- Agoraphobia - complications Agoraphobia - genetics Agoraphobia - psychology
- Anxiety - genetics Anxiety - psychology
- Case-Control Studies -
- Chromosomes, Human, Pair 1 - genetics
- DNA Primers -
- Humans -
- Linkage Disequilibrium -
- Odds Ratio -
- Panic Disorder - genetics Panic Disorder - psychology
- Polymorphism, Single Nucleotide - genetics
- Psychiatric Status Rating Scales -
- RGS Proteins - genetics
- Reverse Transcriptase Polymerase Chain Reaction -
- Find related publications in this database (Keywords)
- Rgs2
- chromosome 1q31
- panic disorder
- linkage disequilibrium
- polymorphisms
- case-control-study