Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hutterer, GC; Sobolev, N; Ehrlich, GC; Gutschi, T; Stojakovic, T; Mannweiler, S; Pummer, K; Zigeuner, R; Pichler, M; Dalpiaz, O.
Pretreatment lymphocyte-monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma.
J Clin Pathol. 2015; 68(5):351-355
Doi: 10.1136/jclinpath-2014-202658
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hutterer Georg
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Dalpiaz Orietta
- Ehrlich Georg
- Gutschi Thomas
- Mannweiler Sebastian
- Pummer Karl
- Stojakovic Tatjana
- Zigeuner Richard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- To investigate the potential prognostic impact of the lymphocyte-monocyte ratio (LMR) in a large European cohort of patients with localised upper urinary tract urothelial carcinoma (UTUC). The LMR as an indicator of systemic inflammatory response has been shown to represent a potential prognostic factor in various types of human cancers. Up to date, the prognostic significance of the LMR in UTUC has not been evaluated. Clinico-pathological data from 182 non-metastatic patients with UTUC, operated between 1990 and 2012 at a single tertiary academic centre, were evaluated retrospectively. Pretreatment LMR was assessed 1 day before surgery. Patients were categorised using an LMR cut-off value of 2.0 according to a calculation by receiver-operating curve analysis. Patients' overall survival (OS) was assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the LMR, a multivariate proportional Cox regression model was applied for OS. In multivariate analyses, age on the date of surgery (<65 vs ≥65 years, HR=2.10, 95% CI 1.22 to 3.64), pathological T-stage (pT1 vs pT2-4, HR=2.15, 95% CI 1.26 to 3.67), as well as the LMR (<2 vs ≥2, HR=0.56, 95% CI 0.35 to 0.92) were independent predictors of OS of patients with UTUC. In the cohort studied, patients with an elevated (≥2) preoperative LMR had a subsequently longer OS after radical surgery for UTUC, compared with those with a low (<2) preoperative LMR. Thus, we believe this parameter might be considered an additional prognostic factor in UTUC in the future. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Aged -
- Aged, 80 and over -
- Area Under Curve -
- Area Under Curve -
- Carcinoma - blood
- Carcinoma - pathology
- Carcinoma - therapy
- Chi-Square Distribution -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Lymphocyte Count -
- Lymphocytes -
- Male -
- Middle Aged -
- Monocytes -
- Multivariate Analysis -
- Neoplasm Staging -
- Predictive Value of Tests -
- Proportional Hazards Models -
- ROC Curve -
- Retrospective Studies -
- Risk Factors -
- Time Factors -
- Treatment Outcome -
- Urologic Neoplasms - blood
- Urologic Neoplasms - mortality
- Urologic Neoplasms - pathology
- Urologic Neoplasms - therapy
- Urothelium - pathology