Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Falkensammer, J; Frech, A; Duschek, N; Gasteiger, S; Stojakovic, T; Scharnagl, H; Huber, K; Fraedrich, G; Greiner, A.
Prognostic relevance of ischemia-modified albumin and NT-proBNP in patients with peripheral arterial occlusive disease.
Clin Chim Acta. 2015; 438(1):255-260
Doi: 10.1016/j.cca.2014.08.031
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Scharnagl Hubert
- Stojakovic Tatjana
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- Abstract:
- Cardiovascular morbidity is high among patients with peripheral arterial occlusive disease (PAOD). The aim of this study was to evaluate the ability of ischemia-modified albumin (IMA), N-terminal proBNP (NT-proBNP), and high-sensitive cardiac Troponin T (hs-cTnT) to predict cardiovascular complications in male patients with Fontaine stage II PAOD. 68 men with stage II PAOD underwent treadmill testing. NT-proBNP, IMA and hs-cTnT were measured before and after exercise. Patients were followed up prospectively and complete follow-up data were available for 66 individuals. Median follow-up time was 43.0months. 12 (18.2%) patients had suffered from a major adverse cardiac event (MACE). IMA and NT-proBNP baseline concentrations were significantly higher in patients who developed MACE during follow-up: IMA: 110.6±2.4kU/L vs. 102.5±0.9kU/L (p<0.001); NT-proBNP: 270.5±295.9ng/L vs. 84.6±15.4ng/L (p=0.007). In multivariable regression models only IMA was significantly associated with the primary endpoint (HR=1.07, CI 1.01-1.13; p=0.029). In the present study, a serum concentration of >103.9kU/L of IMA was a better independent predictor of MACE than NT-proBNP or hs-cTnT. IMA might be a valuable tool for risk stratification in PAOD patients. Copyright © 2014 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - blood
- Exercise Test -
- Follow-Up Studies -
- Humans -
- Male -
- Middle Aged -
- Natriuretic Peptide, Brain - blood
- Oxidative Stress -
- Peptide Fragments - blood
- Peripheral Arterial Disease - blood
- Peripheral Arterial Disease - diagnosis
- Peripheral Arterial Disease - physiopathology
- Prognosis -
- Prospective Studies -
- Risk Factors -
- Serum Albumin -
- Serum Albumin, Human -
- Troponin T - blood
- Find related publications in this database (Keywords)
- Peripheral arterial disease
- Cardiovascular risk
- Oxidative stress
- Ischemia-modified albumin
- High-sensitivity cardiac Troponin T
- NT-proBNP