Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, E; Trojan, A; Schuster, SJ; Haybaeck, J.
Progressive multifocal leukoencephalopathy--a case report and review of the literature.
In Vivo. 2014; 28(5):941-948
(- Case Report)
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
- Taucher Elisabeth
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- Abstract:
- Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system which affects the white matter and is caused by reactivation of the JC polyomavirus. We report the case of a 63-year-old man with chronic lymphocytic leukemia who was treated with fludarabine; rituximab and fludarabine; fludarabine, cyclophsphamide and rituximab; and lenalidomide. While he underwent chemotherapy, the patient was diagnosed with PML. After stabilization of PML, the patient underwent non-myeloablative allogeneic bone marrow transplantation as a treatment for chronic lymphocytic leukemia. Unfortunately, after several opportunistic infections, the patient died. The patient underwent allogeneic bone marrow transplantation with the expectation that donor-derived competent immunological cells would migrate into the cerebral lesions, maintaining immunological response. The effect of bone marrow transplantation in patients with PML requires investigation in larger patient series. Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Brain - pathology
- Fatal Outcome -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Leukemia, Lymphocytic, Chronic, B-Cell - complications
- Leukemia, Lymphocytic, Chronic, B-Cell - therapy
- Leukoencephalopathy, Progressive Multifocal - diagnosis
- Leukoencephalopathy, Progressive Multifocal - etiology
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Polyomavirus Infections - complications
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- Leukoencephalopathy
- progressive multifocal
- JC virus
- demyelinating diseases
- therapy