Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, E; Haybaeck, J.
Non-coding RNAs and lipid metabolism.
Int J Mol Sci. 2014; 15(8):13494-13513
Doi: 10.3390/ijms150813494
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- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
- Taucher Elisabeth
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- Abstract:
- A high percentage of the mammalian genome consists of non-coding RNAs (ncRNAs). Among ncRNAs two main subgroups have been identified: long ncRNAs (lncRNAs) and micro RNAs (miRNAs). ncRNAs have been demonstrated to play a role in a vast variety of diseases, since they regulate gene transcription and are involved in post-transcriptional regulation. They have the potential to function as molecular signals or as guides for transcription factors and to regulate epigenetic modifiers. In this literature review we have summarized data on miRNAs and lncRNAs and their involvement in dyslipidaemia, atherosclerosis, insulin resistance and adipogenesis. Outlining certain ncRNAs as disease biomarkers and/or therapeutic targets, and testing them in vivo, will be the next steps in future research.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipogenesis -
- Atherosclerosis - genetics
- Dyslipidemias - genetics
- Humans -
- Lipid Metabolism - genetics
- MicroRNAs - genetics
- Oxidative Stress - genetics
- RNA, Untranslated - genetics
- Find related publications in this database (Keywords)
- non-coding RNAs
- micro RNAs
- long non-coding RNAs
- dyslipidaemia