Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoffmann, KM; Grabowski, M; Rödl, S; Deutschmann, A; Schwantzer, G; Sovinz, P; Strenger, V; Urban, C; Muntean, W; Hauer, AC.
Short-term intravenous fish-oil emulsions in pediatric oncologic patients--effect on liver parameters.
Nutr Cancer. 2014; 66(6):1070-1076
Doi: 10.1080/01635581.2014.916316
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hoffmann Karl Martin
- Co-Autor*innen der Med Uni Graz
- Deutschmann Andrea
- Hauer Almuthe
- Muntean Eugen
- Ritter-Sovinz Petra
- Roedl Siegfried
- Schwantzer Gerold
- Strenger Volker
- Urban Ernst-Christian
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- Abstract:
- Pediatric oncologic patients often need parenteral nutrition (PN) during chemotherapy. Long-term use of soybean-based lipid emulsions is associated with progressive liver disease and cholestasis, whereas fish-oil based emulsions have anticholestatic effects. We studied the potentially hepato-protective effects of short-term use of SMOF lipids in children undergoing chemotherapy. Fifteen pediatric oncologic patients treated with SMOF lipids were retrospectively analyzed in respect to bilirubin and liver parameters and compared to matched-controls who had received soybean-based fat emulsions. For statistics the time-points baseline, Day 14 of PN (PN14), and post (Day+7) were chosen. None of the study patients developed cholestasis. Within the SMOF-lipid group there were no differences in the laboratory parameters between baseline, PN14, and post. In the control group, gamma glutamyltransferase (γGT) levels increased during PN (baseline vs. PN14, 26.43 vs. 63.00 U/l, P < 0.05). Lactate dehydrogenase (LDH) levels showed a significantly different behavior in the 2 groups: In the SMOF lipids group, LDH decreased whereas it increased in the controls (-32.75 U/l vs. + 29.57 U/l, P < 0.05). An advantage of fish oil-based fat emulsions can be shown even after short-term PN. In children undergoing chemotherapy the use of soybean-based fat emulsions but not SMOF lipids led to increased γGT levels.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Intravenous -
- Adolescent -
- Bilirubin - metabolism
- Child -
- Child, Preschool -
- Cholestasis - chemically induced Cholestasis - pathology
- Emulsions -
- Female -
- Fish Oils - administration & dosage Fish Oils - adverse effects
- Humans -
- L-Lactate Dehydrogenase - metabolism
- Liver - drug effects Liver - metabolism
- Male -
- Parenteral Nutrition - adverse effects
- Retrospective Studies -
- Soybean Oil - administration & dosage Soybean Oil - adverse effects
- Time Factors -
- gamma-Glutamyltransferase - metabolism