Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brunner, SM; Farzi, A; Locker, F; Holub, BS; Drexel, M; Reichmann, F; Lang, AA; Mayr, JA; Vilches, JJ; Navarro, X; Lang, R; Sperk, G; Holzer, P; Kofler, B.
GAL3 receptor KO mice exhibit an anxiety-like phenotype.
Proc Natl Acad Sci U S A. 2014; 111(19):7138-7143
Doi: 10.1073/pnas.1318066111
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- Führende Autor*innen der Med Uni Graz
- Farzi Aitak
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Reichmann Florian
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- Abstract:
- The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems. It is a modulator of various physiological and pathological processes, and it mediates its effects via three G protein-coupled receptors (GAL1-3 receptors). A role for GAL as a modulator of mood and anxiety was suggested, because GAL and its receptors are highly expressed in limbic brain structures of rodents. In recent years, numerous studies of animal models have suggested an involvement of GAL and GAL1 and GAL2 receptors in anxiety- and depression-related behavior. However, to date, there is sparse literature implicating GAL3 receptors in behavioral functions. Therefore, we studied the behavior of GAL3 receptor-deficient (GAL3-KO) mice to elucidate whether GAL3 receptors are involved in mediating behavior-associated actions of GAL. The GAL3-KO mouse line exhibited normal breeding and physical development. In addition to behavioral tests, phenotypic characterization included analysis of hematology, amino acid profiles, metabolism, and sudomotor function. In contrast to WT littermates, male GAL3-KO mice exhibited an anxiety-like phenotype in the elevated plus maze, open field, and light/dark box tests, and they were less socially affiliated than WT animals to a stranger mouse in a social interaction test. In conclusion, our data suggest involvement of GAL3 receptors in GAL-mediated effects on mood, anxiety, and behavior, making it a possible target for alternative treatment strategies for mood disorders.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anxiety Disorders - genetics
- Anxiety Disorders - physiopathology
- Behavior, Animal - physiology
- Depressive Disorder - genetics
- Depressive Disorder - physiopathology
- Female -
- Male -
- Mice -
- Mice, Knockout -
- Models, Animal -
- Phenotype -
- Receptor, Galanin, Type 3 - genetics
- Receptor, Galanin, Type 3 - metabolism
- Serotonin - metabolism
- Social Behavior -
- Sweat Glands - physiology
- Find related publications in this database (Keywords)
- galanin receptor
- serotonin
- Gcat variant 2