Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Scharnagl, H; Kleber, ME; Genser, B; Kickmaier, S; Renner, W; Weihrauch, G; Grammer, T; Rossmann, C; Winkelmann, BR; Boehm, BO; Sattler, W; März, W; Malle, E.
Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography--the LURIC study.
Int J Cardiol. 2014; 174(1):96-105
Doi: 10.1016/j.ijcard.2014.03.168
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- Führende Autor*innen der Med Uni Graz
- Malle Ernst
- Scharnagl Hubert
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Renner Wilfried
- Rossmann Christine Renate
- Sattler Wolfgang
- Weihrauch Gisela
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- Abstract:
- The phagocytic enzyme myeloperoxidase (MPO) acts as a front-line defender against microorganisms. However, increased MPO levels have been found to be associated with complex and calcified atherosclerotic lesions and incident cardiovascular disease. Therefore, this study aimed to investigate a predictive role of MPO, a biomarker of inflammation and oxidative stress, for total and cardiovascular mortality in patients referred to coronary angiography. MPO plasma concentrations along with eight MPO polymorphisms were determined in 3036 participants of the Ludwigshafen Risk and Cardiovascular Health study (median follow-up 7.75 years). MPO concentrations were positively associated with age, diabetes, smoking, markers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein, serum amyloid A) and vascular damage (vascular cellular adhesion molecule-1 and intercellular adhesion molecule-1) but negatively associated with HDL-cholesterol and apolipoprotein A-I. After adjustment for cardiovascular risk factors MPO concentrations in the highest versus the lowest quartile were associated with a 1.34-fold risk (95% CI: 1.09-1.67) for total mortality. In the adjusted model the hazard ratio for cardiovascular mortality in the highest MPO quartile was 1.42 (95% CI: 1.07-1.88). Five MPO polymorphisms were positively associated with MPO concentrations but not with mortality. Using Mendelian randomization, we did not obtain evidence for a causal association of MPO with either total or cardiovascular mortality. MPO concentrations but not genetic variants at the MPO locus are independently associated with risk for total and cardiovascular mortality in coronary artery disease patients. Copyright © 2014. Published by Elsevier Ireland Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers - blood
- Cardiovascular Diseases - genetics
- Cardiovascular Diseases - mortality
- Coronary Angiography -
- Female -
- Humans -
- Male -
- Middle Aged -
- Peroxidase - blood
- Peroxidase - genetics
- Polymorphism, Genetic -
- Predictive Value of Tests -
- Risk -
- Find related publications in this database (Keywords)
- Myeloperoxidase
- Inflammation
- High-density lipoprotein
- Cardiovascular mortality
- Risk factor